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    Article

    Subtypes of medulloblastoma have distinct developmental origins

    Medulloblastomas, a common type of malignant childhood brain tumour, are thought in the main to arise from the cerebellum, many of them involving aberrant signalling of a signalling pathway involving Sonic Hed...

    Paul Gibson, Yiai Tong, Giles Robinson, Margaret C. Thompson, D. Spencer Currle… in Nature (2010)

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    Article

    Cross-species genomics matches driver mutations and cell compartments to model ependymoma

    Ependymoma is a type of neural tumour that arises throughout the central nervous system. Using comparative transcriptomics in mouse and human tumours, Johnson et al. home in on mutations that are specific to indi...

    Robert A. Johnson, Karen D. Wright, Helen Poppleton, Kumarasamypet M. Mohankumar… in Nature (2010)

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    Article

    Prominin 1 marks intestinal stem cells that are susceptible to neoplastic transformation

    Inappropriate activation of the Wnt signalling pathway in intestinal stem cells causes them to become cancerous. Two papers in this issue help identify the cell type at the root of this cancer, which should in...

    Liqin Zhu, Paul Gibson, D. Spencer Currle, Yiai Tong, Robert J. Richardson… in Nature (2009)