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Open AccessE2-25K SUMOylation inhibits proteasome for cell death during cerebral ischemia/reperfusion
Cerebral ischemia/reperfusion (I/R) causes brain damage accompanied by ubiquitin accumulation and impairment of proteasome activity. In this study, we report that E2-25K, an E2-conjugating enzyme, is SUMOylate...
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Open AccessThe DUSP26 phosphatase activator adenylate kinase 2 regulates FADD phosphorylation and cell growth
Adenylate kinase 2 (AK2), which balances adenine nucleotide pool, is a multi-functional protein. Here we show that AK2 negatively regulates tumour cell growth. AK2 forms a complex with dual-specificity phospha...
