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Article
Open AccessAuthor Correction: Impaired CD4+ T cell response in older adults is associated with reduced immunogenicity and reactogenicity of mRNA COVID-19 vaccination
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Article
Open AccessImpaired CD4+ T cell response in older adults is associated with reduced immunogenicity and reactogenicity of mRNA COVID-19 vaccination
Whether age-associated defects in T cells impact the immunogenicity and reactogenicity of mRNA vaccines remains unclear. Using a vaccinated cohort (n = 216), we demonstrated that older adults (aged ≥65 years) had...
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Protocol
Clonogenic Culture of Mouse Thymic Epithelial Cells
The thymus plays an essential role in the development and selection of T cells by providing a unique microenvironment that is mainly composed of thymic epithelial cells (TECs). We previously identified stem ce...
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Article
Open AccessImpaired airway mucociliary function reduces antigen-specific IgA immune response to immunization with a claudin-4-targeting nasal vaccine in mice
Vaccine delivery is an essential element for the development of mucosal vaccine, but it remains to be investigated how physical barriers such as mucus and cilia affect vaccine delivery efficacy. Previously, we...
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Article
Open AccessCrucial role of the Rap G protein signal in Notch activation and leukemogenicity of T-cell acute lymphoblastic leukemia
The Rap G protein signal regulates Notch activation in early thymic progenitor cells and deregulated Rap activation (Raphigh) results in the development of Notch-dependent T-cell acute lymphoblastic leukemia (T-A...
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Article
Medullary thymic epithelial cells expressing Aire represent a unique lineage derived from cells expressing claudin
The autoimmune regulator Aire is expressed in a small proportion of medullary thymic epithelial cells (mTECs) and is crucial in the induction of central T cell tolerance. The origin and development of Aire+ mTECs...
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Article
Tec is involved in G protein-coupled receptor- and integrin-mediated signalings in human blood platelets
Tec is a non-receptor type tyrosine kinase which is tyrosine phosphorylated and activated upon stimulation of hematopoietic cells with various cytokines. The role of Tec in G protein-coupled receptor- and inte...
