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Article
Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity
As aberrant accumulation of RNA–DNA hybrids (R-loops) causes DNA damage and genome instability, cells express regulators of R-loop structures. Here we report that RNA-dependent RNA polymerase (RdRP) activity o...
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Article
Open AccessA molecular glue RBM39-degrader induces synthetic lethality in cancer cells with homologous recombination repair deficiency
E7820 and Indisulam (E7070) are sulfonamide molecular glues that modulate RNA splicing by degrading the splicing factor RBM39 via ternary complex formation with the E3 ligase adaptor DCAF15. To identify biomar...
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Article
Open AccessApplicability of enzymatic and phenol–sulfuric acid methods for determination of cellulose nanofibers in ecotoxicity testing
In parallel with the development of novel materials, such as cellulose nanofibers (CNFs), their effects on aquatic organisms should be evaluated. In ecotoxicity testing, concentration measurements are importan...
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Article
Open AccessThe development of a custom RNA-sequencing panel for the identification of predictive and diagnostic biomarkers in glioma
Various molecular profiles are needed to classify malignant brain tumors, including gliomas, based on the latest classification criteria of the World Health Organization, and their poor prognosis necessitates ...
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Article
Open AccessAcute toxicity tests of TEMPO-oxidized cellulose nanofiber using Daphnia magna and Oryzias latipes
Ecotoxicity data on cellulose nanofibers (CNFs) are limited despite their wide application prospects. Herein, acute toxicity tests of 2,2,6,6-tetramethylpiperidine-1-oxyl radical (TEMPO)-oxidized CNFs to Daphnia ...
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Article
Open AccessPromoter swap** of truncated PDGFRB drives Ph-like acute lymphoblastic leukemia
Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL) is a subset of ALL that demonstrated a high treatment failure rate. One of the hallmarks of Ph-like ALL is PDGFRB gene fusion, with fusion p...
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Article
Subclonal accumulation of immune escape mechanisms in microsatellite instability-high colorectal cancers
Intratumor heterogeneity (ITH) in microsatellite instability-high (MSI-H) colorectal cancer (CRC) has been poorly studied. We aimed to clarify how the ITH of MSI-H CRCs is generated in cancer evolution and how...
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Article
Open AccessSomatic mutations can induce a noninflamed tumour microenvironment via their original gene functions, despite deriving neoantigens
Identifying biomarkers to predict immune checkpoint inhibitor (ICI) efficacy is warranted. Considering that somatic mutation-derived neoantigens induce strong immune responses, patients with a high tumour muta...
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Article
Open AccessIdentification of novel prognostic and predictive biomarkers in salivary duct carcinoma via comprehensive molecular profiling
Molecular targets and predictive biomarkers for prognosis in salivary duct carcinoma (SDC) have not been fully identified. We conducted comprehensive molecular profiling to discover novel biomarkers for SDC. A...
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Article
Open AccessPreclinical assessment of combination therapy of EGFR tyrosine kinase inhibitors in a highly heterogeneous tumor model
The development of tyrosine kinase inhibitors (TKIs) has improved the treatment of non-small cell lung cancer (NSCLC) with epidermal growth factor receptor (EGFR) mutations. The current research priority is to...
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Article
Variation in chronic nickel toxicity to Daphnia magna among Japanese river waters and performance evaluation of bioavailability models in predicting the toxicity
Nickel (Ni) ecotoxicity is dictated by water chemistry characteristics such as pH, water hardness, and amount of dissolved organic carbon. Bioavailability models have been developed to predict Ni toxicity and ...
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Article
Open AccessGenetic diagnosis of pseudomyxoma peritonei originating from mucinous borderline tumor inside an ovarian teratoma
Pseudomyxoma peritonei is a rare disease condition mainly caused by primary mucinous tumors from the appendix and rarely from the ovary, such as when mucinous ovarian tumors arise from within a teratoma. Molec...
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Article
Open AccessAuthor Correction: Cell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia
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Article
Open AccessMicroSEC filters sequence errors for formalin-fixed and paraffin-embedded samples
The clinical sequencing of tumors is usually performed on formalin-fixed, paraffin-embedded samples and results in many sequencing errors. We identified that most of these errors are detected in chimeric reads...
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Article
Open AccessTranscript-targeted analysis reveals isoform alterations and double-hop fusions in breast cancer
Although transcriptome alteration is an essential driver of carcinogenesis, the effects of chromosomal structural alterations on the cancer transcriptome are not yet fully understood. Short-read transcript seq...
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Article
Open AccessCell-autonomous megakaryopoiesis associated with polyclonal hematopoiesis in triple-negative essential thrombocythemia
A subset of essential thrombocythemia (ET) cases are negative for disease-defining mutations on JAK2, MPL, and CALR and defined as triple negative (TN). The lack of recurrent mutations in TN-ET patients makes its...
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Article
Multi-omic profiling of peritoneal metastases in gastric cancer identifies molecular subtypes and therapeutic vulnerabilities
Peritoneal metastasis, a hallmark of incurable advanced gastric cancer (GC), presently has no curative therapy and its molecular features have not been examined extensively. Here we present a comprehensive mul...
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Article
Rapid reprogramming of tumour cells into cancer stem cells on double-network hydrogels
Cancer recurrence can arise owing to rare circulating cancer stem cells (CSCs) that are resistant to chemotherapies and radiotherapies. Here, we show that a double-network hydrogel can rapidly reprogramme diff...
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Article
Open AccessComprehensive functional evaluation of variants of fibroblast growth factor receptor genes in cancer
Various genetic alterations of the fibroblast growth factor receptor (FGFR) family have been detected across a wide range of cancers. However, inhibition of FGFR signaling by kinase inhibitors demonstrated lim...
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Article
Open AccessComprehensive molecular profiling of pulmonary pleomorphic carcinoma
Information regarding the molecular features of pulmonary pleomorphic carcinoma (PPC) is insufficient. Here, we performed next-generation sequencing to determine the genomic and transcriptomic profiles of PPC....
