6 Result(s)
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Article
Open AccessTopoisomerase I is an evolutionarily conserved key regulator for satellite DNA transcription
RNA Polymerase (RNAP) II transcription on non-coding repetitive satellite DNAs plays an important role in chromosome segregation, but a little is known about the regulation of satellite transcription. We here ...
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Article
Open AccessUnexpected identification of obesity-associated mutations in LEP and MC4R genes in patients with anorexia nervosa
Mutations leading to a reduced or loss of function in genes of the leptin-melanocortin system confer a risk for monogenic forms of obesity. Yet, gain of function variants in the melanocortin-4-receptor (MC4R) gen...
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Article
Open AccessEvaluation of the MC3R gene pertaining to body weight and height regulation and puberty development
Recent studies reported an impact of the melanocortin 3 receptor (MC3R) on the regulation of body weight, linear growth and puberty timing. Previously, allele p.44Ile of a frequent non-synonymous variant (NSV)...
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Article
Open AccessEvidence for correlations between BMI-associated SNPs and circRNAs
Circular RNAs (circRNAs) are regulators of processes like adipogenesis. Their expression can be modulated by SNPs. We analysed links between BMI-associated SNPs and circRNAs. First, we detected an enrichment o...
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Article
Open AccessT cell-targeting nanoparticles focus delivery of immunotherapy to improve antitumor immunity
Targeted delivery of compounds to particular cell subsets can enhance therapeutic index by concentrating their action on the cells of interest. Because attempts to target tumors directly have yielded limited b...
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Article
Structure-based programming of lymph-node targeting in molecular vaccines
An amphiphile vaccine consisting of a peptide antigen or adjuvant cargo linked to a lipophilic tail is shown to have improved potency and safety in mice by targeting the lymph nodes.
