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Article
Open AccessIncreased hemoglobin and heme in MALDI-TOF MS analysis induce ferroptosis and promote degeneration of herniated human nucleus pulposus
Neovasculogenesis is characteristic of herniated lumbar discs, in which extruded nucleus pulposus is prone to heme iron-induced cytotoxicity (increased oxidative stress causing ferroptosis). However, recent an...
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Article
Open AccessSelective hydroboration of unsaturated bonds by an easily accessible heterotopic cobalt catalyst
Homogeneous earth-abundant metal catalysis based on well-defined molecular complexes has achieved great advance in synthetic methodologies. However, sophisticated ligand, hazardous activator and multistep synt...
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Article
Open AccessPyrinap ligands for enantioselective syntheses of amines
Amines are a class of compounds of essential importance in organic synthesis, pharmaceuticals and agrochemicals. Due to the importance of chirality in many practical applications of amines, enantioselective sy...
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Article
Dual-Channel Enzymatic Inhibition Measurement (DEIM) Coupling Isotope Substrate via Matrix-Assisted Laser Desorption/Ionization Time of Flight Mass Spectrometry
A novel dual-channel enzymatic inhibition measurement (DEIM) method was developed to improve the repeatability with light/heavy isotope substrates, producing reliable relative standard deviations (< 3%) by emp...
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Article
Open AccessGC/MS-based urine metabolomics analysis of renal allograft recipients with acute rejection
Acute renal allograft rejection is a common complication after renal transplantation that often leads to chronic rejection and ultimate graft loss. While renal allograft biopsy remains the gold standard for di...
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Article
Reliable screening of pesticide residues in maternal and umbilical cord sera by gas chromatography-quadrupole time of flight mass spectrometry
The widespread use of pesticides induces heavy adverse effects on human health, especially for the pregnant women and the newborns. In this study, a screening method has been developed for the determination of...
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Chapter
Chemical and Biochemical Applications of MALDI TOF-MS Based on Analyzing the Small Organic Compounds
This review focuses on the recent applications of matrix-assisted laser desorption ionization time of flight mass spectrometry (MALDI TOF-MS) technologies for analysis of small molecular compounds (SMCs) on qu...
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Article
Analysis of Volatile Compounds in Radix Bupleuri Injection by GC–MS–MS
Static headspace sampling, headspace solid-phase microextraction, and direct immersion solid-phase microextraction coupled with gas chromatography–tandem mass spectrometry have been developed for determination...
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Article
Integration of High Accuracy N-Terminus Identification in Peptide Sequencing and Comparative Protein Analysis Via Isothiocyanate-Based Isotope Labeling Reagent with ESI Ion-trap TOF MS
A multifunctional isothiocyanate-based isotope labeling reagent, [d 0]-/[d 6]-4,6-dimethoxy pyrimidine-2-isothiocyanate (DMPITC), has been developed for accurate N-terminus identif...
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Article
Studies on gas-phase cyclometalations of [ArNi(PPh3)n]+ (n = 1 or 2) by electrospray ionization tandem mass spectrometry
Gas-phase cyclometalation of [ArNi(PPh3)n]+ (n = 1, 2) complexes have been studied by ESI-MS/MS. The electron-donating substituents of aromatic iodides in the para position were found to inhibit the cyclometalati...
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Article
Monitoring enzyme reaction and screening of inhibitors of acetylcholinesterase by quantitative matrix-assisted laser desorption/ionization fourier transform mass spectrometry
A matrix-assisted laser desorption/ionization Fourier transform mass spectrometry (MALDI-FTMS)-based assay was developed for kinetic measurements and inhibitor screening of acetylcholinesterase. Here, FTMS cou...
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Article
Selective determination of pyridine alkaloids in tobacco by PFTBA ions/analyte molecule reaction ionization ion trap mass spectrometry
The application of perfluorotributylamine (PFTBA) ions/analyte molecule reaction ionization for the selective determination of tobacco pyridine alkaloids by ion trap mass spectrometry (IT-MS) is reported. The ...
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Article
Highly efficient and selective enrichment of phosphopeptides using porous anodic alumina membrane for MALDI-TOF MS analysis
Because of its good biocompatibility, high surface-to-volume ratio, and distinct surface electrical properties, porous anodic alumina (PAA) membrane has been used to selectively enrich phosphopeptides from a m...
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Article
Porous anodic alumina membrane as a sample support for MALDI-TOF MS analysis of salt-containing proteins
Matrix-assisted laser desorption/ionization time-of-flight mass spectrometric (MALDI-TOF MS) analysis of proteins in salt-containing solution was performed for the first time using porous anodic alumina (PAA) ...
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Article
Using amino acids for probing structural information of cytochrome c by electrospray ionization mass spectrometry
By using electrospray ionization mass spectrometry (ESI-MS), protein complexes of cytochrome c with amino acids were studied. Different amino acids were investigated to explore these complexes. Using these amino ...
