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Article
Open AccessDiphthamide deficiency promotes association of eEF2 with p53 to induce p21 expression and neural crest defects
Diphthamide is a modified histidine residue unique for eukaryotic translation elongation factor 2 (eEF2), a key ribosomal protein. Loss of this evolutionarily conserved modification causes developmental defect...
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Article
Open AccessGrowth and development of children under 5 years of age with tetralogy of Fallot in a Chinese population
Congenital Heart Defects (CHDs) are associated with different patterns of malnutrition and growth retardation, which may vary worldwide and need to be evaluated according to local conditions. Although tetralog...
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Article
Open AccessThe lateralization of left hippocampal CA3 during the retrieval of spatial working memory
The hippocampal CA3 contributes to spatial working memory (SWM), but which stage of SWM the CA3 neurons act on and whether the lateralization of CA3 function occurs in SWM is also unknown. Here, we reveal incr...
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Article
Open AccessLongitudinal Association of Sleep Duration with Depressive Symptoms among Middle-aged and Older Chinese
This study aimed to evaluate the associations of nighttime sleep duration and midday nap** with risk of depressive symptoms incidence and persistence among middle-aged and older Chinese. Data from China Heal...
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Article
Open AccessMild traumatic brain injury induces memory deficits with alteration of gene expression profile
Repeated mild traumatic brain injury (rmTBI), the most common type of traumatic brain injuries, can result in neurological dysfunction and cognitive deficits. However, the molecular mechanisms and the long-ter...
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Article
Open AccessRegulation of global gene expression and cell proliferation by APP
Down syndrome (DS), caused by trisomy of chromosome 21, is one of the most common genetic disorders. Patients with DS display growth retardation and inevitably develop characteristic Alzheimer’s disease (AD) n...
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Article
Open AccessNighttime sleep duration, 24-hour sleep duration and risk of all-cause mortality among adults: a meta-analysis of prospective cohort studies
A dose-response meta-analysis was conducted to summarize evidence from prospective cohort studies about the association of nighttime sleep duration and 24-hour sleep duration with risk of all-cause mortality a...
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Article
Open AccessInhibition of actin polymerization in the NAc shell inhibits morphine-induced CPP by disrupting its reconsolidation
Drug-associated contextual cues contribute to drug craving and relapse after abstinence, which is a major challenge to drug addiction treatment. Previous studies showed that disrupting memory reconsolidation i...