-
Article
Novel IL36RN Mutation Identified in Pediatric-Onset Generalized Pustular Psoriasis Causes IL36 Antagonist Degradation
-
Article
Open AccessInhibition of cystathionine β-synthase promotes apoptosis and reduces cell proliferation in chronic myeloid leukemia
Increased endogenous hydrogen sulfide (H2S) level by cystathionine β-synthase (CBS) has been shown to closely relate tumorigenesis. H2S promotes angiogenesis, stimulates bioenergy metabolism and inhibits selectiv...
-
Article
Open AccessTranslational Inhibition of α-Neurexin 2
Neurexins are extensively investigated presynaptic cell-adhesion molecules which play important roles in transmitting signals and processing information at synapses that connect neurons into a vast network of ...
-
Article
Open AccessTranscriptional activation of USP16 gene expression by NFκB signaling
Ubiquitin Specific Peptidase 16 (USP16) has been reported to contribute to somatic stem-cell defects in Down syndrome. However, how this gene being regulated is largely unknown. To study the mechanism underlying
-
Article
Traumatic Brain Injury Alters the Metabolism and Facilitates Alzheimer’s Disease in a Murine Model
A majority of Alzheimer’s disease (AD) cases are sporadic without known cause. People who suffered from traumatic brain injury (TBI) are more likely to develop neurodegeneration and cognitive impairments. Howe...
-
Article
Ethanol Alters APP Processing and Aggravates Alzheimer-Associated Phenotypes
The majority of Alzheimer’s disease (AD) cases are sporadic with unknown causes. Many dietary factors including excessive alcohol intake have been reported to increase the risk to develop AD. The effect of alc...
-
Article
Regulation of SET Gene Expression by NFkB
SET is elevated and mislocalized in the neuronal cytoplasm in brains of Alzheimer’s disease (AD) and Down syndrome (DS) patients. Cytoplasm SET leads to inhibition of protein phosphatase 2A and is involved in ...
-
Article
Open AccessRegulation of global gene expression and cell proliferation by APP
Down syndrome (DS), caused by trisomy of chromosome 21, is one of the most common genetic disorders. Patients with DS display growth retardation and inevitably develop characteristic Alzheimer’s disease (AD) n...
-
Article
Open AccessTwo novel DNA motifs are essential for BACE1 gene transcription
BACE1 gene encodes for β-Site amyloid β precursor protein (APP)-cleaving enzyme1, which is required for generating amyloid β protein(Aβ). Deposition of Aβ in brain plays an essential role in Alzheimer's Disease (...
-
Article
Sp1 Regulates Human Huntingtin Gene Expression
Huntington’s disease (HD) is a hereditary neurodegenerative disorder resulting from the expansion of a polyglutamine tract in the huntingtin protein. The expansion of cytosine–adenine–guanine repeats results i...
-
Article
QTL map** for chromium-induced growth and zinc, and chromium distribution in seedlings of a rice DH population
Chromium contamination in soil has become a severe threat to crop production and food safety. The experiment was conducted using a rice DH population to detect the QTLs associated with Cr tolerance. Seventeen ...
-
Article
Open AccessTranscriptional Regulation of TMP21 by NFAT
TMP21 is a member of the p24 cargo protein family, which is involved in protein transport between the Golgi apparatus and ER. Alzheimer's Disease (AD) is the most common neurodegenerative disorder leading to d...
-
Article
BACE1 Gene Promoter Single-Nucleotide Polymorphisms in Alzheimer’s Disease
Alzheimer’s disease (AD) is the most neurodegenerative disorder leading to dementia. Neuritic plaque formation in brains is a hallmark of AD pathogenesis. Amyloid β protein (Aβ) is the central component of neu...
-
Article
The screening of mutants and construction of mutant library for Oryza sativa cv. Nipponbare via ethyl methane sulphonate inducing
Following the sequencing of rice genome, the functional analysis of unidentified genes is gaining wide importance. Mutant isolation is one of the effective ways to isolate and clone the target genes and analyz...
-
Article
Identification of Cr-tolerant lines in a rice (Oryza sativa) DH population
Identification of Cr-tolerant lines in a rice DH population was conducted based on the modified weighted function analysis. The significant difference was found between the two parents and among DH population ...
-
Chapter and Conference Paper
Terahertz Digital Holography
Recent years, Terahertz (THz) radiation which occupied an extremely large portion of the electromagnetic spectrum between the microwave and infrared has drawn much attention and interest, since the rapid advan...
