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Article
Open AccessControl of false discoveries in grouped hypothesis testing for eQTL data
Expression quantitative trait locus (eQTL) analysis aims to detect the genetic variants that influence the expression of one or more genes. Gene-level eQTL testing forms a natural grouped-hypothesis testing st...
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Article
Open AccessFast Multivariate Probit Estimation via a Two-Stage Composite Likelihood
The multivariate probit is popular for modeling correlated binary data, with an attractive balance of flexibility and simplicity. However, considerable challenges remain in computation and in devising a clear ...
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Article
Open AccessC3NA: correlation and consensus-based cross-taxonomy network analysis for compositional microbial data
Studying the co-occurrence network structure of microbial samples is one of the critical approaches to understanding the perplexing and delicate relationship between the microbe, host, and diseases. It is also...
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Article
Open AccessA resource for integrated genomic analysis of the human liver
In this study, we generated whole-transcriptome RNA-Seq from n = 192 genotyped liver samples and used these data with existing data from the GTEx Project (RNA-Seq) and previous liver eQTL (microarray) studies to ...
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Article
A Two-Stage Hidden Markov Model Design for Biomarker Detection, with Application to Microbiome Research
It has been recognized that for appropriately ordered data, hidden Markov models (HMM) with local false discovery rate (FDR) control can increase the power to detect significant associations. For many high-thr...
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Article
Open AccessGenome-wide association meta-analysis identifies five modifier loci of lung disease severity in cystic fibrosis
The identification of small molecules that target specific CFTR variants has ushered in a new era of treatment for cystic fibrosis (CF), yet optimal, individualized treatment of CF will require identification and...
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Article
Historical development and future perspectives of Environmental Specimen Bank in China: a mini review
Environmental problems as well as their related ecosystem stress and human health risk in China have raised wide concerns along with the rapid economic development in recent years. Numerous studies with a shar...
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Article
Heritability and genomics of gene expression in peripheral blood
Fred Wright, Patrick Sullivan and colleagues present the results of a large expression QTL study of peripheral blood using a classic twin design with follow-up replication in independent samples. Their results...
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Article
Stochastic comparisons in a price-quantity setting firm with uncertain demand and emergency procurement
We consider a newsvendor problem with price-dependent demand, in either additive or multiplicative format. The newsvendor has two modes of purchasing: regular ordering at the beginning of the selling season an...
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Article
Skill-assessments of statistical and Ensemble Kalman Filter data assimilative analyses using surface and deep observations in the Gulf of Mexico
A new data assimilation algorithm (Quasi-EnKF) in ocean modeling, based on the Ensemble Kalman Filter scheme, is proposed in this paper. This algorithm assimilates not only surface measurements (sea surface he...
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Article
Single Nucleotide Polymorphism (SNP) Detection and Genotype Calling from Massively Parallel Sequencing (MPS) Data
Massively parallel sequencing (MPS), since its debut in 2005, has transformed the field of genomic studies. These new sequencing technologies have resulted in the successful identification of causal variants f...
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Article
Adaptive Evolution of Saccharomyces cerevisiae in a Continuous and Closed Circulating Fermentation (CCCF) System Coupled with PDMS Membrane Pervaporation
As an efficient means of strain improvement, adaptive evolution is a technique with great potential. Long-term cultivation of Saccharomyces cerevisiae was performed in a polydimethylsiloxane membrane bioreactor s...
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Article
Heavy Metals in Hair of Residents in an E-Waste Recycling Area, South China: Contents and Assessment of Bodily State
Heavy metals were measured in hair from occupationally and nonoccupationally exposed populations in an e-waste recycling area and from residents from a control rural town. The levels of five heavy metals were ...
