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Article
Open AccessControl of false discoveries in grouped hypothesis testing for eQTL data
Expression quantitative trait locus (eQTL) analysis aims to detect the genetic variants that influence the expression of one or more genes. Gene-level eQTL testing forms a natural grouped-hypothesis testing st...
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Article
Open AccessThe Genotype-Tissue Expression (GTEx) project
Genome-wide association studies have identified thousands of loci for common diseases, but, for the majority of these, the mechanisms underlying disease susceptibility remain unknown. Most associated variants ...
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Article
Open AccessBasal-like Breast cancer DNA copy number losses identify genes involved in genomic instability, response to therapy, and patient survival
Breast cancer is a heterogeneous disease with known expression-defined tumor subtypes. DNA copy number studies have suggested that tumors within gene expression subtypes share similar DNA Copy number aberratio...
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Article
Open AccessThe molecular portraits of breast tumors are conserved across microarray platforms
Validation of a novel gene expression signature in independent data sets is a critical step in the development of a clinically useful test for cancer patient risk-stratification. However, validation is often u...
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Chapter and Conference Paper
Significance and Recovery of Block Structures in Binary Matrices with Noise
Frequent itemset mining (FIM) is one of the core problems in the field of Data Mining and occupies a central place in its literature. One equivalent form of FIM can be stated as follows: given a rectangular da...
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Chapter
Consistent Estimation of a Dynamical Map
Estimation of a nonlinear map F governing the evolution of an observed dynamical system is considered in two specific models. In the first model, F is successively applied to a fixed initial vector in the abse...
