-
Article
Open AccessControl of false discoveries in grouped hypothesis testing for eQTL data
Expression quantitative trait locus (eQTL) analysis aims to detect the genetic variants that influence the expression of one or more genes. Gene-level eQTL testing forms a natural grouped-hypothesis testing st...
-
Article
Open AccessInsight into genetic regulation of miRNA in mouse brain
micro RNA (miRNA) are important regulators of gene expression and may influence phenotypes and disease traits. The connection between genetics and miRNA expression can be determined through expression quantita...
-
Article
Open AccessAuthor Correction: Eya3 partners with PP2A to induce c-Myc stabilization and tumor progression
In the original version of this Article, the title of the legend to Fig. 7 incorrectly read ‘Knockdown of B55α increases breast cancer metastasis’ instead of ‘Knockdown of B55α decreases breast cancer metastas...
-
Article
Open AccessPredictive modeling of miRNA-mediated predisposition to alcohol-related phenotypes in mouse
MicroRNAs (miRNAs) are small non-coding RNAs that bind messenger RNAs and promote their degradation or repress their translation. There is increasing evidence of miRNAs playing an important role in alcohol rel...
-
Article
Open AccessEya3 partners with PP2A to induce c-Myc stabilization and tumor progression
Eya genes encode a unique family of multifunctional proteins that serve as transcriptional co-activators and as haloacid dehalogenase-family Tyr phosphatases. Intriguingly, the N-terminal domain of Eyas, which...
-
Article
Open AccessModel based heritability scores for high-throughput sequencing data
Heritability of a phenotypic or molecular trait measures the proportion of variance that is attributable to genotypic variance. It is an important concept in breeding and genetics. Few methods are available fo...
