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Article
Open AccessValidation of a breast cancer risk prediction model based on the key risk factors: family history, mammographic density and polygenic risk
We compared a simple breast cancer risk prediction model, BRISK (which includes mammographic density, polygenic risk and clinical factors), against a similar model with more risk factors (simplified Rosner) an...
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Article
Open AccessCharacteristics and fetal outcomes of pregnant women with hypertensive disorders in China: a 9-year national hospital-based cohort study
Hypertensive disorders of pregnancy (HDP) are a growing concern and a challenge for maternity care providers as the prevalence of hypertension continues to increase. However, optimal management of HDP is uncle...
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Article
Open AccessTemporal trends and adverse perinatal outcomes of twin pregnancies at differing gestational ages: an observational study from China between 2012–2020
With the development of assisted reproductive technology, the twinning rate in China has been increasing. However, little is known about twinning from 2014 onwards. In addition, previous studies analysing opti...
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Article
Open AccessPregnancy complications and risk of uterine rupture among women with singleton pregnancies in China
The goal of this study was to investigate whether pregnancy complications are associated with an increased risk of uterine rupture (UR) and how that risk changes with gestational age.
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Article
Potential role of glutathione S-transferase P1 gene polymorphism and metabolic syndrome in lower urinary tract symptoms attributed to benign prostatic hyperplasia
The aim of the study is to investigate the effects of glutathione S-transferase P1 (GSTP1) gene polymorphism and metabolic syndrome (MS) on lower urinary tract symptoms (LUTS) attributed to benign prostatic hyper...
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Article
Open AccessPerformance of the point-of-care circulating cathodic antigen test in the diagnosis of schistosomiasis japonica in a human cohort from Northern Samar, the Philippines
Zoonotic schistosomiasis, caused by Schistosoma japonicum, remains a major public health problem in the Philippines. This study aimed to evaluate the commercially available rapid diagnostic point-of-care circulat...
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Article
Open AccessThe incidence, risk factors and maternal and foetal outcomes of uterine rupture during different birth policy periods: an observational study in China
Currently, there are no studies on changes in the incidence of uterine rupture or maternal and foetal outcomes in women with uterine rupture during different birth policy periods in China. Moreover, the result...
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Article
Open AccessThe trends and associated adverse maternal and perinatal outcomes of labour neuraxial analgesia among vaginal deliveries in China between 2012 and 2019: a real-world observational evidence
There is a lack of national report of the labour neuraxial analgesia (NA) rates in China in recent years, especially after the national promotion policy. The adverse maternal and perinatal outcomes associated ...
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Article
Open AccessApgar score and neonatal mortality in China: an observational study from a national surveillance system
To examine the association between the Apgar score and neonatal mortality over gestational age in China and to explore whether this association changed when Apgar scores were combined at 1 and 5 min.
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Article
Cognitive and fatigue side effects of anti-epileptic drugs: an analysis of phase III add-on trials
We aimed to investigate the terms used to refer to cognitive and fatigue related side effects and their prevalence in phase III add-on clinical trials of anti-epileptic drugs (AEDs). We extracted data from pub...
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Article
Open AccessChanges in prevalence and perinatal outcomes of congenital hydrocephalus among Chinese newborns: a retrospective analysis based on the hospital-based birth defects surveillance system
Little is known about the epidemiology of congenital hydrocephalus (CH) in China. This study aimed to depict recent changes in CH prevalence and perinatal outcomes of the affected newborns.
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Article
Open AccessAmniotic fluid embolism as a cause of maternal mortality in China between 1996 and 2013: a population-based retrospective study
To analyse the maternal mortality ratio, demographic and pregnancy related details in women who suffered a fatal amniotic fluid embolism (AFE) in China.
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Article
Privacy-Preserving and Secure Sharing of PHR in the Cloud
As a new summarized record of an individual’s medical data and information, Personal Health Record (PHR) can be accessible online. The owner can control fully his/her PHR files to be shared with different user...
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Article
Radiofrequency Ablation Plus Devascularization Is the Preferred Treatment of Hepatocellular Carcinoma with Esophageal Varices
Most hepatocellular carcinomas (HCCs) are associated with cirrhosis. Portal hypertension (PHT) and esophageal variceal bleeding (EVB) can limit the patient’s treatment options. Surgical therapy in such patient...
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Article
Open AccessPerinatal mortality in pregnancies with omphalocele: data from the Chinese national birth defects monitoring network, 1996–2006
Previous studies on the mortality rate of omphalocele are limited. The risk of death of non-isolated omphalocele and that of cases of omphalocele that are diagnosed prenatally by ultrasound are unclear. This s...
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Article
Personal Health Record Systems and Their Security Protection
The objective of this study is to analyze the security protection of personal health record systems. To achieve this we have investigated different personal health record systems, their security functions, and...
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Article
Enhanced radiation damage of tumor vasculature by mTOR inhibitors
It is known that radiation activates the phosphoinositol-3 kinase (PI3K)/Akt pathway and that inhibition of PI3K or Akt sensitizes tumor vasculature to radiotherapy. Mammalian target of rapamycin (mTOR) is a d...
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Article
Erratum: XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer
Correction to: Oncogene (2004) 23, 7047–7052. doi: 10.1038/sj.onc.1207929 Since publication of the above manuscript, the authors have identified an error in the ‘Materials and methods’ section of this paper. O...
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Article
XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer
Survivin and XIAP are members of inhibitors of apoptosis (IAPs) family. They are upregulated in various malignancies. Inactivation of these molecules has resulted in chemosensitization. The purpose of this stu...