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7 Result(s)

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  1. Article

    Open Access

    Factors based on optical coherence tomography correlated with vision impairment in diabetic patients

    The aim of this study is to evaluate the relationship between retinal structures and visual acuity in diabetic patients using optical coherence tomography (OCT) and OCT angiography (OCTA). This study was a ret...

    Hiroaki Endo, Satoru Kase, Hikari Tanaka, Mitsuo Takahashi… in Scientific Reports (2021)

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  2. Article

    Open Access

    Infliximab versus intravenous immunoglobulin for refractory Kawasaki disease: a phase 3, randomized, open-label, active-controlled, parallel-group, multicenter trial

    We compared the efficacy and safety of infliximab with intravenous immunoglobulin (IVIG), a standard therapy, in a phase 3 trial (NCT01596335) for Japanese patients with Kawasaki disease (KD) showing persisten...

    Masaaki Mori, Takuma Hara, Masako Kikuchi, Hiroyuki Shimizu… in Scientific Reports (2018)

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  3. No Access

    Article

    Influenza neuraminidase operates via a nucleophilic mechanism and can be targeted by covalent inhibitors

    Development of novel influenza neuraminidase inhibitors is critical for preparedness against influenza outbreaks. Knowledge of the neuraminidase enzymatic mechanism and transition-state analogue, 2-deoxy-2,3-d...

    Christopher J. Vavricka, Yue Liu, Hiromasa Kiyota… in Nature Communications (2013)

  4. Article

    Open Access

    Experimental adaptation of an influenza H5 HA confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets

    Only four mutations in H5N1 HA are required to enable ferret-to-ferret transmission of a reassortant virus containing the H5 HA and the remaining seven gene segments from a human pandemic H1N1 influenza virus.

    Masaki Imai, Tokiko Watanabe, Masato Hatta, Subash C. Das, Makoto Ozawa… in Nature (2012)

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  5. No Access

    Article

    Haemagglutinin mutations responsible for the binding of H5N1 influenza A viruses to human-type receptors

    The fact that the H5N1 bird flu virus circulating in Asia, Europe and Africa is unable to attach to human-type cell receptors has helped to prevent it from causing a worldwide epidemic of a human variant of th...

    Shinya Yamada, Yasuo Suzuki, Takashi Suzuki, Mai Q. Le, Chairul A. Nidom… in Nature (2006)

  6. Article

    Isolation of drug-resistant H5N1 virus

    The full report on an H5N1 avian flu virus isolate resistant to Tamiflu (oseltamivir) has added to concerns about preparations for a flu pandemic. The virus was from a Vietnamese girl given the drug as both pr...

    Q. Mai Le, Maki Kiso, Kazuhiko Someya, Yuko T. Sakai, T. Hien Nguyen… in Nature (2005)

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  7. Article

    Enhanced virulence of influenza A viruses with the haemagglutinin of the 1918 pandemic virus

    The ‘Spanish’ influenza pandemic of 1918–19 was the most devastating outbreak of infectious disease in recorded history. At least 20 million people1 died from their illness, which was characterized by an unusuall...

    Darwyn Kobasa, Ayato Takada, Kyoko Shinya, Masato Hatta, Peter Halfmann… in Nature (2004)

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