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    Article

    Enhancing Temozolomide (TMZ) chemosensitivity using CRISPR-dCas9-mediated downregulation of O6-methylguanine DNA methyltransferase (MGMT)

    Glioblastoma (GBM) stands out as the most prevalent and aggressive intracranial tumor, notorious for its poor prognosis. The current standard-of-care for GBM patients involves surgical resection followed by ra...

    Yasamin Yousefi, Reza Nejati, Atiye Eslahi, Farzaneh Alizadeh in Journal of Neuro-Oncology (2024)

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    Production of Duchenne muscular dystrophy cellular model using CRISPR-Cas9 exon deletion strategy

    Duchenne Muscular Dystrophy (DMD) is a progressive muscle wasting disorder caused by loss-of-function mutations in the dystrophin gene. Although the search for a definitive cure has failed to date, extensive e...

    Farzaneh Alizadeh, Yousef Jafari Abraghan in Molecular and Cellular Biochemistry (2024)

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    Investigating the Effects of Temporin-Rb, an Antimicrobial Peptide, on Cell Viability and Pro-inflammatory Gene Expression in A549 Cells

    This study investigates the effects of Temporin-Rb, an antimicrobial peptide, on A549 cells’ viability and pro-inflammatory gene expression. The MTT assay revealed a dose- and time-dependent reduction in cell ...

    Niloufar Shakibapour, Ahmad Asoodeh in International Journal of Peptide Research … (2023)