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Article
Enhancing Temozolomide (TMZ) chemosensitivity using CRISPR-dCas9-mediated downregulation of O6-methylguanine DNA methyltransferase (MGMT)
Glioblastoma (GBM) stands out as the most prevalent and aggressive intracranial tumor, notorious for its poor prognosis. The current standard-of-care for GBM patients involves surgical resection followed by ra...
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Article
Production of Duchenne muscular dystrophy cellular model using CRISPR-Cas9 exon deletion strategy
Duchenne Muscular Dystrophy (DMD) is a progressive muscle wasting disorder caused by loss-of-function mutations in the dystrophin gene. Although the search for a definitive cure has failed to date, extensive e...
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Article
Investigating the Effects of Temporin-Rb, an Antimicrobial Peptide, on Cell Viability and Pro-inflammatory Gene Expression in A549 Cells
This study investigates the effects of Temporin-Rb, an antimicrobial peptide, on A549 cells’ viability and pro-inflammatory gene expression. The MTT assay revealed a dose- and time-dependent reduction in cell ...