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  1. No Access

    Article

    Enhancing Temozolomide (TMZ) chemosensitivity using CRISPR-dCas9-mediated downregulation of O6-methylguanine DNA methyltransferase (MGMT)

    Glioblastoma (GBM) stands out as the most prevalent and aggressive intracranial tumor, notorious for its poor prognosis. The current standard-of-care for GBM patients involves surgical resection followed by ra...

    Yasamin Yousefi, Reza Nejati, Atiye Eslahi, Farzaneh Alizadeh… in Journal of Neuro-Oncology (2024)

  2. Article

    Open Access

    The conserved p.Arg108 residue in S1PR2 (DFNB68) is fundamental for proper hearing: evidence from a consanguineous Iranian family

    Genetic heterogeneity and consanguineous marriages make recessive inherited hearing loss in Iran the second most common genetic disorder. Only two reported pathogenic variants (c.323G>C, p.Arg108Pro and c.419A...

    Michaela A. H. Hofrichter, Majid Mojarad, Julia Doll, Clemens Grimm… in BMC Medical Genetics (2018)

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