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Article
Enhancing Temozolomide (TMZ) chemosensitivity using CRISPR-dCas9-mediated downregulation of O6-methylguanine DNA methyltransferase (MGMT)
Glioblastoma (GBM) stands out as the most prevalent and aggressive intracranial tumor, notorious for its poor prognosis. The current standard-of-care for GBM patients involves surgical resection followed by ra...
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Article
Production of Duchenne muscular dystrophy cellular model using CRISPR-Cas9 exon deletion strategy
Duchenne Muscular Dystrophy (DMD) is a progressive muscle wasting disorder caused by loss-of-function mutations in the dystrophin gene. Although the search for a definitive cure has failed to date, extensive e...
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Article
Generation of Zebrafish Models of Human Retinitis Pigmentosa Diseases Using CRISPR/Cas9-Mediated Gene Editing System
Generating animal models can explore the role of new candidate genes in causing diseases and the pathogenicity of a specific mutation in the underlying genes. These animals can be used to identify new pharmace...
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Article
The \((2 + 1)\) -dimensional generalized time-fractional Zakharov Kuznetsov Benjamin Bona Mahony equation: its classical and nonclassical symmetries, exact solutions, and conservation laws
In the present paper, a model of the gravitational waves of water known as the \((2 + 1)\) ...
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Article
Open AccessTMEM263: a novel candidate gene implicated in human autosomal recessive severe lethal skeletal dysplasia
Skeletal dysplasia is a common, clinically and genetically heterogeneous disorder in the human population. An increasing number of different genes are being identified causing this disorder. We used whole exom...
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Article
Non-classical Lie symmetry and conservation laws of the nonlinear time-fractional Kundu–Eckhaus (KE) equation
This work provides an analytical investigation of the time-fractional Kundu–Eckhaus (KE) equation. We use the symmetry of the Lie group as an appropriate tool which deals with the wide class of fractional-orde...
