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Article
Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2
The transcription factor E2F-1 plays a pivotal role in the regulation of G1/S transition in higher eukaryotes cell cycle. We used a cell line containing an inducible E2F-1 and oligonucleotide microarray analys...
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Article
E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis
The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation in higher eukaryotes. We used DNA microarrays and cell lines containing either inducible E2F-1 or inducible ...
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Article
Inferring gene regulatory logic from high-throughput measurements of thousands of systematically designed promoters
Analyzing the effects of multiple promoter motifs on gene expression can be a laborious process. Sharon et al. present a high-throughput method to measure the expression of thousands of designed yeast promoters i...
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Article
Derivation of novel human ground state naive pluripotent stem cells
It is known that human embryonic stem (ES) cells are more similar to mouse primed epiblast stem cells than to naive mouse ES cells; here culture conditions are determined that allow human ES and induced plurip...
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Article
Correction: Corrigendum: Derivation of novel human ground state naive pluripotent stem cells
Nature 504, 282–286 (2013); doi:10.1038/nature12745 The reduced representation bisulphite sequencing (RRBS) data generated and analysed in this Letter were not originally uploaded to the Gene Expression Omnibu...
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Article
Impaired function of trophoblast cells derived from translocated hESCs may explain pregnancy loss in women with balanced translocation (11;22)
The aim of the study was to study whether the trophoblasts carrying unbalanced translocation 11,22 [t(11;12)] display abnormal expression of trophoblastic genes and impaired functional properties that may expl...
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Article
Blastomere biopsy for PGD delays embryo compaction and blastulation: a time-lapse microscopic analysis
The purpose of the study was to explore the effect of blastomere biopsy for preimplantation genetic diagnosis (PGD) on the embryos’ dynamics, further cleavage, development, and implantation.
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Article
Open AccessThe effect of a germline mutation in the APC gene on β-catenin in human embryonic stem cells
Most cases of colorectal cancer (CRC) are initiated by inactivation mutations in the APC gene, which is a negative regulator of the Wnt-β-catenin pathway. Patients with familial adenomatous polyposis (FAP) inh...
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Article
Time-lapse imaging reveals delayed development of embryos carrying unbalanced chromosomal translocations
The purpose of the study was to compare the morphokinetic parameters of embryos carrying balanced chromosomal translocations with those carrying unbalanced chromosomal translocations using time-lapse microscopy.
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Chapter and Conference Paper
Automated Measurements of Key Morphological Features of Human Embryos for IVF
A major challenge in clinical In-Vitro Fertilization (IVF) is selecting the highest quality embryo to transfer to the patient in the hopes of achieving a pregnancy. Time-lapse microscopy provides clinicians wi...
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Article
Effects of letrozole or tamoxifen coadministered with a standard stimulation protocol on fertility preservation among breast cancer patients
To assess the effects of letrozole or tamoxifen coadministration on fertility preservation treatment outcomes.
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Article
Transfer of Day 6 Frozen-Thawed Blastocysts on Day 5 Compared with Day 6: Catching Up with the Window of Implantation—a Retrospective Study
To compare clinical pregnancy rate (CPR) and live birth rate (LBR) after frozen-thawed embryo transfer (FET) of day (D-) 6 blastocysts on D-5 versus D-6. A retrospective cohort study. A university-affiliated s...
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Article
Gonadotropin-Releasing Hormone Agonist Versus Recombinant Human Chorionic Gonadotropin Triggering in Fertility Preservation Cycles
The purpose of this research is to study the efficacy of GnRH-a versus r-hCG triggering in patients who go through fertility preservation cycles. This retrospective cohort study was performed in a tertiary uni...
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Article
The association between a carrier state of FMR1 premutation and numeric sex chromosome variations
Women carriers of FMR1 premutation are at increased risk of early ovarian dysfunction and even premature ovarian insufficiency. The aim of this study was to examine a possible association between FMR1 permutat...
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Article
Open AccessIsoform-resolved transcriptome of the human preimplantation embryo
Human preimplantation development involves extensive remodeling of RNA expression and splicing. However, its transcriptome has been compiled using short-read sequencing data, which fails to capture most full-l...
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Article
A clinical predictive model for live birth in women of advanced age undergoing PGT cycles
The trend of delaying childbirth has resulted in a growing number of advanced-aged women who are opting for preimplantation genetic testing (PGT) to screen for monogenic diseases or structural chromosomal rear...
