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  1. Article

    Open Access

    The lincRNA JUNI regulates the stress-dependent induction of c-Jun, cellular migration and survival through the modulation of the DUSP14-JNK axis

    Cancer cells employ adaptive mechanisms to survive various stressors, including genotoxic drugs. Understanding the factors promoting survival is crucial for develo** effective treatments. In this study, we u...

    Vikash Kumar, Xavier Sabaté-Cadenas, Isha Soni, Esther Stern, Carine Vias… in Oncogene (2024)

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  2. Article

    Open Access

    Theileria parasites subvert E2F signaling to stimulate leukocyte proliferation

    Intracellular pathogens have evolved intricate mechanisms to subvert host cell signaling pathways and ensure their own propagation. A lineage of the protozoan parasite genus Theileria infects bovine leukocytes an...

    Kyle Tretina, Malak Haidar, Sally A. Madsen-Bouterse, Takaya Sakura… in Scientific Reports (2020)

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  3. Article

    Open Access

    The long non-coding RNA ERIC is regulated by E2F and modulates the cellular response to DNA damage

    The human genome encodes thousands of unique long non-coding RNAs (lncRNAs), and these transcripts are emerging as critical regulators of gene expression and cell fate. However, the transcriptional regulation ...

    Orit Feldstein, Tal Nizri, Tirza Doniger, Jasmine Jacob, Gideon Rechavi… in Molecular Cancer (2013)

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  4. No Access

    Article

    p53 and E2f: partners in life and death

  5. There is extensive crosstalk between the Rb–E2f and MDM2–p53 pathways, and specifically between the transcription factors E2F1 and p53, which influences vital ...

    6. Shirley Polager, Doron Ginsberg in Nature Reviews Cancer (2009)

  6. No Access

    Article

    ATM is a target for positive regulation by E2F-1

    The E2F-1 transcription factor is a critical downstream target of the tumor suppressor, RB. When activated, E2F-1 induces cell proliferation. In addition, deregulation of E2F-1 constitutes an oncogenic stress ...

    Eli Berkovich, Doron Ginsberg in Oncogene (2003)

  7. No Access

    Article

    E2Fs up-regulate expression of genes involved in DNA replication, DNA repair and mitosis

    The E2F family of transcription factors plays a pivotal role in the regulation of cell proliferation in higher eukaryotes. We used DNA microarrays and cell lines containing either inducible E2F-1 or inducible ...

    Shirley Polager, Yael Kalma, Eli Berkovich, Doron Ginsberg in Oncogene (2002)

  8. No Access

    Article

    Expression analysis using DNA microarrays demonstrates that E2F-1 up-regulates expression of DNA replication genes including replication protein A2

    The transcription factor E2F-1 plays a pivotal role in the regulation of G1/S transition in higher eukaryotes cell cycle. We used a cell line containing an inducible E2F-1 and oligonucleotide microarray analys...

    Yael Kalma, Lea Marash, Yocheved Lamed, Doron Ginsberg in Oncogene (2001)

  9. No Access

    Article

    Binding and modulation of p53 by p300/CBP coactivators

    The adenovirus E1A and SV40 large-T-antigen oncoproteins bind to members of the p300/CBP transcriptional coactivator family. Binding of p300/CBP is implicated in the transforming mechanisms of E1A and T-antige...

    Nancy L. Lill, Steven R. Grossman, Doron Ginsberg, James DeCaprio… in Nature (1997)