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  1. Article

    Open Access

    Biomarker correlates with response to NY-ESO-1 TCR T cells in patients with synovial sarcoma

    Autologous T cells transduced to express a high affinity T-cell receptor specific to NY-ESO-1 (letetresgene autoleucel, lete-cel) show promise in the treatment of metastatic synovial sarcoma, with 50% overall ...

    Alexandra Gyurdieva, Stefan Zajic, Ya-Fang Chang… in Nature Communications (2022)

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  2. Article

    Open Access

    Lasofoxifene as a potential treatment for therapy-resistant ER-positive metastatic breast cancer

    Endocrine therapy remains the mainstay of treatment for estrogen receptor-positive (ER+) breast cancer. Constitutively active mutations in the ligand binding domain of ERα render tumors resistant to endocrine ...

    Muriel Lainé, Sean W. Fanning, Ya-Fang Chang, Bradley Green… in Breast Cancer Research (2021)

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  3. No Access

    Article

    MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11

    Chemotherapy resistance frequently drives tumour progression. However, the underlying molecular mechanisms are poorly characterized. Epithelial-to-mesenchymal transition has been shown to correlate with therap...

    Jessica Bockhorn, Rachel Dalton, Chika Nwachukwu, Simo Huang… in Nature Communications (2013)

  4. No Access

    Article

    MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion

    Metastasis remains a significant challenge in treating cancer. A better understanding of the molecular mechanisms underlying metastasis is needed to develop more effective treatments. Here, we show that human ...

    Jessica Bockhorn, Kathy Yee, Ya-Fang Chang… in Breast Cancer Research and Treatment (2013)

  5. No Access

    Article

    Synthesis of 2′-Deoxy-2′-[18F]Fluoro-9-β-D-Arabinofuranosylguanine: a Novel Agent for Imaging T-Cell Activation with PET

    9-(β-D-Arabinofuranosyl)guanine (AraG) is a guanosine analog that has a proven efficacy in the treatment of T-cell lymphoblastic disease. To test the possibility of using a radiofluorinated AraG as an imaging age...

    Mohammad Namavari, Ya-Fang Chang, Brenda Kusler… in Molecular Imaging and Biology (2011)