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Article
Open AccessNovel MYC-driven medulloblastoma models from multiple embryonic cerebellar cells
Group3 medulloblastoma (MBG3) that predominantly occur in young children are usually associated with MYC amplification and/or overexpression, frequent metastasis and a dismal prognosis. Physiologically relevant M...
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Article
Open AccessKRAS mutation leads to decreased expression of regulator of calcineurin 2, resulting in tumor proliferation in colorectal cancer
KRAS mutations occur in 30–40% of all cases of human colorectal cancer (CRC). However, to date, specific therapeutic agents against KRAS-mutated CRC have not been developed. We previously described the generation...
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Article
GNASR201H and KrasG12D cooperate to promote murine pancreatic tumorigenesis recapitulating human intraductal papillary mucinous neoplasm
Intraductal papillary mucinous neoplasm (IPMN), the most common pancreatic cystic neoplasm, is known to progress to invasive ductal adenocarcinoma. IPMNs commonly harbor activating somatic mutations in GNAS and K...
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Article
Open AccessPrevalence of polymorphisms of the genes responsible for auto-inflammatory diseases among 236 patients with recurrent fever in a rheumatology institute in Japan
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Article
The Composition Pulling Effect in MOVPE Grown InGaN on GaN and AlGaN and its TEM Characterization
InGaN films have been grown on GaN and AlGaN epitaxial layers by metalorganic vapor phase epitaxy. The “composition pulling effect” during the initial InGaN growth stages has been studied as a function of the ...
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Article
Open AccessPReS-FINAL-2125: A Japanese girl with childhood-onset anti-Ku antibody positive generalized morphea-myositis overlap syndrome
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Article
Collision Dynamics of Non-Abelian Vortices in Spinor Bose-Einstein Condensates
Bose-Einstein condensates with spin degrees of freedom admit various topological phases and excitations. Non-Abelian vortices offer a remarkable example which is expected to be realized in the cyclic phase of ...
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Article
Open AccessInverse correlation of HER2 with MHC class I expression on oesophageal squamous cell carcinoma
As HER2 is expressed in 30% of oesophageal squamous cell carcinomas (ESCCs), T-cell-based immunotherapy and monoclonal antibodies targeted against HER2 are attractive, novel approaches for ESCCs. However, it w...
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Article
Open AccessInterleukin-21 can efficiently restore impaired antibody-dependent cell-mediated cytotoxicity in patients with oesophageal squamous cell carcinoma
We previously reported that Trastuzumab- and Cetuximab-mediated antibody-dependent cell-mediated cytotoxicity (ADCC) in cancer patients was impaired in comparison with that in healthy donors because of NK-cell...
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Article
Improvement in the FF over 0.700 by controlling the interface quality
In this study, the pn hetero-interface between Zn(O,S,OH)x buffer and Cu(InGa)(SSe)2 (CIGSS) surface layers is discussed in order to achieve the fill factor (FF) over 0.73 and the circuit efficiency of 16 % on ap...
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Article
Selective expression of MHC class I in the affected muscle of a patient with idiopathic inflammatory myopathy
The dominant clinical feature of polymyositis/dermatomyositis is weakness in proximal, rather than distal, musculature. Although rare, cases of focal/localized myositis in which polymyositis-like muscle inflam...
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Article
Improvement of the interface quality between Zn (O,S,OH)x buffer and Cu(InGa)(SeS)2 surface layers to enhance the fill factor over 0.700
For realizing the proof of mass production capability or a move toward a GW/a production, 16%-efficiency project has been started setting the target of each parameter as Voc: 0.685 V/cell, FF: 0.735 and Jsc: 31.8...
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Article
Evolution of the photoresponse time of the GaAs/AlGaAs cyclotron resonance quantum Hall effect detector
The photoresponse time of the cyclotron resonance detector to terahertz radiation under integer quantum Hall effect conditions in the GaAs/AlGaAs heterostructure is shown to have a deep minimum at the Hall pla...
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Chapter and Conference Paper
Turbulent Drag Reduction with Surfactant Additives — Basic Research and Application to an Air Conditioning System
It is well known that a small amount of chemicals such as water-soluble polymers or surfactants dramatically suppresses turbulence when they are added to liquid flow at large Reynolds number. In the last two d...
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Chapter and Conference Paper
DNS study on “diameter effect” of drag reduction in viscoelastic-fluid flow
It is well known that the small amount of polymers or surfactant additives to flowing liquid give rise to drag reduction (DR) in turbulent flow [1]. However this mechanism has not been satisfactorily clarified...
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Chapter and Conference Paper
DNS of turbulent plane Couette flow with emphasis on turbulent stripe
Reverse transition of ‘turbulence → laminar’ in wall-bounded shear flows remains poorly understood and few studies have been reported. A plane Couette flow (CF) is conceptually one of the simplest non-trivial ...
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Chapter and Conference Paper
Statistical Characteristics of Elastic Turbulence in a Free-Surface Swirling Flow
By using both conventional particle image velocimetry (PIV) and high-speed dynamic PIV, the statistical characteristics of elastic turbulence in a free-surface swirling flow were studied. Flow patterns of the ...
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Article
Open AccessDownregulation of HLA Class I molecules in the tumour is associated with a poor prognosis in patients with oesophageal squamous cell carcinoma
As antigenic peptides in the context of human leukocyte antigen (HLA) class I molecules are recognised by cytotoxic T lymphocytes (CTL), the downregulation of HLA class I molecules is one of the reasons why tu...
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Article
Open AccessLocalisation pattern of Foxp3+ regulatory T cells is associated with clinical behaviour in gastric cancer
It has been reported that the population of regulatory T cells (T regs) is increased in tumour-infiltrating lymphocytes in cancer-bearing hosts. Recently, forkhead/winged helix transcription factor p3, Foxp3, ...
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Article
Fatty liver and obesity: phenotypically correlated but genetically distinct traits in a mouse model of type 2 diabetes
Obesity and fatty liver are commonly associated with type 2 diabetes, but the genetic and functional bases linking fatty liver with obesity and diabetes are largely unknown. Our aim was to investigate the asso...
