33 Result(s)

Article

S100A6 Regulates nucleus pulposus cell apoptosis via Wnt/β-catenin signaling pathway: an in vitro and in vivo study

Intervertebral disc degeneration (IDD) is a common musculoskeletal degenerative disease, which often leads to low back pain and even disability, resulting in loss of labor ability and decreased quality of life...

Fengguang Yang, Yanni Duan, Yanhu Li, Daxue Zhu, Zhaoheng Wang… in Molecular Medicine (2024)

Article

Combined emapalumab and ruxolitinib in patients with haemophagocytic Lymphohistiocytosis

Yue Song, Fei Zhou, Feng Du, Ziyan Wang, Liyun Bai, Yifang Yao… in Blood Cancer Journal (2024)

Article

Echinococcus granulosus ubiquitin-conjugating enzymes (E2D2 and E2N) promote the formation of liver fibrosis in TGFβ1-induced LX-2 cells

Cystic echinococcosis (CE) is a widespread zoonosis caused by the infection with Echinococcus granulosus sensu lato (E. granulosus s.l.). CE cysts mainly develop in the liver of intermediate hosts, characterized ...

**aodi Du, Ruiqi Hua, Xue He, Wei Hou, Shengqiong Li, Aiguo Yang… in Parasites & Vectors (2024)

Article

Identification of diagnostic model in heart failure with myocardial fibrosis and conduction block by integrated gene co-expression network analysis

Despite the advancements in heart failure(HF) research, the early diagnosis of HF continues to be a challenging issue in clinical practice. This study aims to investigate the genes related to myocardial fibros...

Yonghua Yuan, Yiwei Niu, Jiajun Ye, Yuejuan Xu, Xuehua He, Sun Chen in BMC Medical Genomics (2024)

Article

System analysis based on the pyroptosis-related genes identifes GSDMD as a novel therapy target for skin cutaneous melanoma

Skin cutaneous melanoma (SKCM) is the most aggressive skin cancer, accounting for more than 75% mortality rate of skin-related cancers. As a newly identified programmed cell death, pyroptosis has been found to...

Shixin Zhao, Yongkang Zhu, Hengdeng Liu, Xuefeng He… in Journal of Translational Medicine (2023)

Article

Molecular characterization and functional implications on mouse peripheral blood mononuclear cells of annexin proteins from Echinococcus granulosus sensu lato

Cystic echinococcosis (CE) is a life-threatening zoonotic disease caused by the larval stage of Echinococcus granulosus sensu lato, which employs various strategies to evade the host immune system for survival. R...

Xue He, Guoqing Shao, **aodi Du, Ruiqi Hua, Hongyu Song, Yanxin Chen… in Parasites & Vectors (2023)

Article

Liver metastasis from colorectal cancer: pathogenetic development, immune landscape of the tumour microenvironment and therapeutic approaches

Colorectal cancer liver metastasis (CRLM) is one of the leading causes of death among patients with colorectal cancer (CRC). Although immunotherapy has demonstrated encouraging outcomes in CRC, its benefits ar...

Yaxian Wang, **nyang Zhong, Xuefeng He… in Journal of Experimental & Clinical Cancer … (2023)

Article

P2X7Rs: new therapeutic targets for osteoporosis

Increasing evidence suggests that both the occurrence and progression of osteoporosis are associated with inflammation, especially in primary osteoporosis. The maintenance of skeletal homeostasis is dependent ...

Haoyun Huang, Yu-Mei He, Miao-Miao Lin, Yanchao Wang… in Purinergic Signalling (2023)

Article

Histones released by NETosis enhance the infectivity of SARS-CoV-2 by bridging the spike protein subunit 2 and sialic acid on host cells

Neutrophil extracellular traps (NETs) can capture and kill viruses, such as influenza viruses, human immunodeficiency virus (HIV), and respiratory syncytial virus (RSV), thus contributing to host defense. Cont...

Weiqi Hong, **gyun Yang, Jun Zou, Zhenfei Bi, Cai He… in Cellular & Molecular Immunology (2022)

Article

Narciclasine induces autophagy-mediated apoptosis in gastric cancer cells through the Akt/mTOR signaling pathway

Gastric cancer is a common gastrointestinal cancer and currently has the third-highest mortality rate. Research shows that the natural compound narciclasine has a variety of biological activities. The present ...

Yunfeng Yuan, Xue He, **ang Li, Yan Liu, Yueliang Tang… in BMC Pharmacology and Toxicology (2021)

Article

Fc receptor-like 1, 3, and 6 variants are associated with rheumatoid arthritis risk in the Chinese Han population

Rheumatoid arthritis (RA) is the most common autoimmune system diseases in our world. More studies in recent years have shown that FCRL gene polymorphisms is closely related to autoimmune diseases. It is suggeste...

Yonghui Yang, Dandan Li, Chunjuan He, Linna Peng, Shishi **ng… in Genes and Environment (2021)

Article

RNA-binding protein IMP3 is a novel regulator of MEK1/ERK signaling pathway in the progression of colorectal Cancer through the stabilization of MEKK1 mRNA

MEK1/ERK signaling pathway plays an important role in most tumor progression, including colorectal cancer (CRC), however, MEK1-targeting therapy has little effective in treating CRC patients, indicating there ...

Meng Zhang, Senlin Zhao, Cong Tan, Yanzi Gu… in Journal of Experimental & Clinical Cancer … (2021)

Article

Comparative analysis of the allergenic characteristics and serodiagnostic potential of recombinant chitinase-like protein-5 and -12 from Sarcoptes scabiei

Scabies is caused by burrowing of the mite Sarcoptes scabiei into the stratum corneum. Currently, diagnosis via routine skin scra** is very difficult, and information on the allergenic identification of S. scab...

Nengxing Shen, Yuhang Chen, Wenrui Wei, Lang **ong, Yuanyuan Tao… in Parasites & Vectors (2021)

Article

Molecular characterization and expression analysis of annexin B3 and B38 as secretory proteins in Echinococcus granulosus

Cystic echinococcosis is a parasitic zoonotic disease, which poses a threat to public health and animal husbandry, and causes significant economic losses. Annexins are a family of phospholipid-binding proteins...

Hongyu Song, Xue He, **aodi Du, Ruiqi Hua, **g Xu, Ran He, Yue **e… in Parasites & Vectors (2021)

Article

Vasculogenic mimicry, a negative indicator for progression free survival of lung adenocarcinoma irrespective of first line treatment and epithelial growth factor receptor mutation status

Vascular mimicry (VM) was associated with the prognosis of cancers. The aim of the study was to explore the association between VM and anticancer therapy response in patients with lung adenocarcinoma.

Xuejun He, Jijun You, Haibing Ding, Zhisheng Zhang, Lin Cui, **aomei Shen… in BMC Cancer (2021)

Article

Astrocyte-derived exosomes enriched with miR-873a-5p inhibit neuroinflammation via microglia phenotype modulation after traumatic brain injury

The interaction between astrocytes and microglia plays a vital role in the damage and repair of brain lesions due to traumatic brain injury (TBI). Recent studies have shown that exosomes act as potent mediator...

**aobing Long, **aolong Yao, Qian Jiang, Yi** Yang… in Journal of Neuroinflammation (2020)

Article

Antibody response of a particle-inducing, liposome vaccine adjuvant admixed with a Pfs230 fragment

Pfs230 is a malaria transmission-blocking antigen candidate, expressed on the surface of Plasmodium falciparum gametocytes. A recombinant, his-tagged Pfs230 fragment (Pfs230C1; amino acids 443–731) formed serum-s...

Wei-Chiao Huang, Bingbing Deng, Amal Seffouh, Joaquin Ortega… in npj Vaccines (2020)

Article

Prognosis value of RBBP8 expression in plasma cell myeloma

Plasma cell myeloma (PCM) secretes monoclonal immunoglobulin (Ig) by clonal plasma cells of abnormal proliferation in the bone marrow. As PCM is incurable, it is necessary to find new biomarkers to predict the...

Weilong Zhang, Ying Song, Xue He, **aoni Liu, Ye Zhang, Zuozhen Yang… in Cancer Gene Therapy (2020)

Article

Complete response to the combination of Lenvatinib and Pembrolizumab in an advanced hepatocellular carcinoma patient: a case report

The majority of patients diagnosed with hepatocellular carcinoma (HCC) have advanced diseases and many are not eligible for curative therapies.

Zhaonan Liu, **ngjie Li, Xuequn He, Yingchun Xu, ** Wang in BMC Cancer (2019)

Article

High expression of UBE2T predicts poor prognosis and survival in multiple myeloma

Multiple myeloma (MM) is one of hematological malignancies, characterized by malignant proliferation of plasma cells. Biomarkers play an important role in evaluating the development and prognosis of MM. Ubiqui...

Weilong Zhang, Ye Zhang, Zuozhen Yang, **aoni Liu, ** Yang… in Cancer Gene Therapy (2019)