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Article
Open AccessTyrosol blocks E. coli anaerobic biofilm formation via YbfA and FNR to increase antibiotic susceptibility
Bacteria within mature biofilms are highly resistant to antibiotics than planktonic cells. Oxygen limitation contributes to antibiotic resistance in mature biofilms. Nitric oxide (NO) induces biofilm dispersal...
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Article
Directed evolution of glycosyltransferase for enhanced efficiency of avermectin glucosylation
Avermectin, produced by Streptomyces avermitilis, is an active compound protective against nematodes, insects, and mites. However, its potential usage is limited by its low aqueous solubility. The uridine diphosp...
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Article
Open AccessDifferential effects of alkyl gallates on quorum sensing in Pseudomonas aeruginosa
Virulence factors and biofilms constitute attractive targets for the prevention of infections caused by multidrug-resistant bacteria. Among alkyl gallates, propyl gallate (PG) and octyl gallate (OG) are used a...
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Article
Open AccessTerrein is an inhibitor of quorum sensing and c-di-GMP in Pseudomonas aeruginosa: a connection between quorum sensing and c-di-GMP
To address the drug-resistance of bacterial pathogens without imposing a selective survival pressure, virulence and biofilms are highly attractive targets. Here, we show that terrein, which was isolated from Aspe...
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Article
Enzymatic synthesis of avermectin B1a glycosides for the effective prevention of the pine wood nematode Bursaphelenchus xylophilus
Avermectin produced by Streptomyces avermitilis is an anti-nematodal agent against the pine wood nematode Bursaphelenchus xylophilus. However, its potential usage is limited by its poor water solubility. For this...
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Article
Open AccessImprovement of the pharmacological activity of menthol via enzymatic β-anomer-selective glycosylation
Menthol has a considerable cooling effect, but the use range of menthol is limited because of its extremely low solubility in water and inherent flavor. (−)-Menthol β-glucoside was determined to be more solubl...
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Article
AN483, a new anti-MRSA compound from Streptomyces sp.
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Article
Verrulactones D and E with unprecedented skeletons, new inhibitors of Staphylococcus aureus enoyl-ACP reductase, from Penicillium verruculosum F375
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Article
Aquastatin C, a new glycoaromatic derivative from Sporothrix sp. FN611
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Article
Isolation of a Calcium-binding Substance from Anchovy
Dried anchovy (Engraulis japonica) was extracted using hot water and filtered with a YM-3 membrane to isolate a calcium binding substance. The membrane filtered solution was fractionated using gel permeation chro...
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Article
Isodeoxyhelicobasidin, a novel human neutrophil elastase inhibitor from the culture broth of Volvariella bombycina
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Article
Macrolactin S, a New Antibacterial Agent with Fab G-inhibitory Activity from Bacillus sp. AT28
In the course of screening for FabG inhibitors from microbial sources, a new 24-membered ring lactone named macrolactin S, along with the known compound macrolactin B, has been isolated from the mycelium of li...
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Article
Viridicatumtoxin B, a new anti-MRSA agent from Penicillium sp. FR11
A new tetracycline-type antibiotic named viridicatumtoxin B along with the known compound viridicatumtoxin has been isolated from the mycelium of liquid fermentation cultures of Penicillium sp. FR11. The structur...
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Article
Verticillin G, a New Antibacterial Compound from Bionectra byssicola
A new epidithiodioxopiperazine compound named verticillin G along with the known compound verticillin D has been isolated from the mycelium of liquid fermentation cultures of a fungal strain Bionectra byssicola F...
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Article
Atromentin and Leucomelone, the First Inhibitors Specific to Enoyl-ACP Reductase (FabK) of Streptococcus pneumoniae
Two potent inhibitors of FabK, the enoyl-acyl carrier protein (ACP) reductase of Streptococcus pneumoniae, were isolated from the solid state fermentation of an unidentified fungus F010248. Their structures were ...
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Article
Talosins A and B: New Isoflavonol Glycosides with Potent Antifungal Activity from Kitasatospora kifunensis MJM341
In our screening program for new antifungal agents from microbial secondary metabolites, we isolated two new isoflavonol glycosides, genistein 7-α-L-6-deoxy-talopyranoside (talosin A) and genistein 4′,7-di-α-L-6-...
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Article
Talosins A and B: New Isoflavonol Glycosides with Potent Antifungal Activity from Kitasatospora kifunensis MJM341
In our screening program for new antifungal agents from microbial secondary metabolites, two new isoflavonol glycosides with potent antifungal activity, talosins A and B, were isolated from the culture broth of K...
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Article
MMA/MPEOMA/VSA copolymer as a novel blood-compatible material: ex vivo platelet adhesion study
MMA/MPEOMA/VSA copolymers with both pendant polyethylene oxide (PEO) side chains and negatively chargeable side groups were synthesized by random copolymerization of methyl methacrylate (MMA), methoxy PEO mono...
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Chapter and Conference Paper
Automatic Regulation of Output of an Electrohydraulic Left Ventricular Assist Device Using the Polymer Bellows Water Pressure and Motor Current
An electrohydraulically driven left ventricular assist device (LVAD) has been developed in our laboratory. Over years of in vitro and in vivo testing, a “suction” problem has been pointed out as one of the maj...
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Chapter and Conference Paper
Further Development of the Moving-Actuator Type Total Artificial Heart
The electromechanical total artificial heart (TAH) developed at Seoul National University Hospital was verified as acceptable for human implantation through several successful animal experiments. In the last t...
