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Article
Open AccessThe efficacy and safety of short-course radiotherapy followed by sequential chemotherapy and Cadonilimab for locally advanced rectal cancer: a protocol of a phase II study
For patients with locally advanced rectal cancer (LARC), total neoadjuvant therapy (TNT), namely, intensifying preoperative treatment through the integration of radiotherapy and systemic chemotherapy before su...
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Article
Open AccessConstruction of an immune-related risk score signature for gastric cancer based on multi-omics data
Early identification of gastric cancer (GC) is associated with a superior survival rate compared to advanced GC. However, the poor specificity and sensitivity of traditional biomarkers suggest the importance o...
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Article
Open AccessA case of Gitelman syndrome with homozygous SLC12A3 deletion presenting with epilepsy
Gitelman syndrome (GS) is a rare autosomal recessive hereditary renal tubular disorder characterized by hypokalemia, metabolic alkalosis, hypomagnesemia, and hypocalciuria.
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Article
Open AccessCrMP-Sol database: classification, bioinformatic analyses and comparison of cancer-related membrane proteins and their water-soluble variant designs
Membrane proteins are critical mediators for tumor progression and present enormous therapeutic potentials. Although gene profiling can identify their cancer-specific signatures, systematic correlations betwee...
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Article
Open AccessResearch on the effectiveness and safety of bronchial thermoplasty in patients with chronic obstructive pulmonary disease
To investigate the clinical efficacy and safety of bronchial thermoplasty (BT) in treating patients with chronic obstructive pulmonary disease (COPD).
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Article
Open AccessThe impact of serum copper on the risk of epilepsy: a mendelian randomization study
The relationship between serum copper and epilepsy has been elucidated in observational studies. In this study, we aimed to explore the causal relationship between serum copper and epilepsy using Mendelian ran...
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Article
Unsupervised domain adaptive tumor region recognition for Ki67 automated assisted quantification
Ki67 is a protein associated with tumor proliferation and metastasis in breast cancer and acts as an essential prognostic factor. Clinical work requires recognizing tumor regions on Ki67-stained whole-slide im...
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Article
A mutant R70V/E166A of short manganese peroxidase showing Mn2+-independent dye decolorization
Il-MnP1, a short-type manganese peroxidase from Irpex lacteus F17, can oxidize some substrates in the absence of Mn2+, but the catalysis was much lower than in the presence of Mn2+. Here, we report a mutant R70V...
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Article
Open AccessPulmonary sclerosing pneumocytoma containing spindle cells with sarcomatoid features: a case report with literature review
Pulmonary sclerosing pneumocytoma (PSP) is an uncommon benign neoplasm originated from pneumocyte and PSP with malignant transformation is extremely rare.
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Article
Open AccessCOVID-19 vaccine attitudes among a majority black sample in the Southern US: public health implications from a qualitative study
The COVID-19 pandemic continues to have high caseloads in the US, with vaccines a critical component of the response. Disparities in COVID-19 morbidity and mortality have been identified across states and raci...
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Article
Open Access11β-HSD1 participates in epileptogenesis and the associated cognitive impairment by inhibiting apoptosis in mice
Glucocorticoid signalling is closely related to both epilepsy and associated cognitive impairment, possibly through mechanisms involving neuronal apoptosis. As a critical enzyme for glucocorticoid action, the ...
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Article
Health Effects of Religion, Spirituality, and Supernatural Beliefs in Mainland China: A Systematic Review
Effects of religion, spirituality and supernatural beliefs (RSS) upon health in mainland China remain poorly understood, despite strong RSS beliefs influencing Chinese society. We conducted a Chinese–English b...
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Open AccessSporadic foveolar-type adenoma in gastric body/antrum junction with gastritis cystica profunda
Sporadic gastric foveolar-type adenomas are extremely rare and are usually small, flat or slightly raised lesions that occur in the oxyntic mucosa.
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Article
Open AccessHIV incidence among men who have sex with men in mainland China: a systematic review protocol
Men who have sex with men (MSM) are disproportionately affected by HIV in China. Globally, younger MSM are at higher risk for incident HIV infections, but there has been substantial variation in the estimates ...
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Article
A potential probiotic bacterium for antipsychotic-induced metabolic syndrome: mechanisms underpinning how Akkermansia muciniphila subtype improves olanzapine-induced glucose homeostasis in mice
Olanzapine (OLZ) is one of the most effective atypical antipsychotics but is associated with severe metabolic side effects, in which the gut microbiota plays an important role. Akkermansia muciniphila (A. mucinip...
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Article
Open AccessEvaluation of the immunomodulatory effects of anti-COVID-19 TCM formulae by multiple virus-related pathways
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Article
Open AccessAdolescent and non-consensual anal sexual debut among Chinese men who have sex with men: a cross-sectional study
Adolescent sexual debut and non-consensual sex have been linked to higher sexual risk and STI infection in adulthood among men who have sex with men (MSM) in high-income countries. This study aimed to examine ...
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Article
Supernatural Explanatory Models of Health and Illness and HIV Antiretroviral Therapy Use Among Young Men Who Have Sex with Men in China
In China, men who have sex with men (MSM) shoulder a disproportionate HIV burden. Early initiation and adherence to HIV antiretroviral therapy (ART) will be critical to reversing the HIV epidemic in China, but...
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Article
Open AccessDLBCL with amplification of JAK2/PD-L2 exhibits PMBCL-like CNA pattern and worse clinical outcome resembling those with MYD88 L265P mutation
Recently, copy number alteration (CNA) of 9p24.1 were demonstrated in 10% of diffuse large b-cell lymphoma (DLBCL), with gene expression and mutation profiles that were similar to those of primary mediastinal ...
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Article
Open AccessThe botanical origin and antioxidant, anti-BACE1 and antiproliferative properties of bee pollen from different regions of South Korea
Bee pollen (BP) has been used as a traditional medicine and food diet additive due to its nutritional and biological properties. The potential biological properties of bee pollen vary greatly with the botanica...