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Article
Exploring the Factors Behind Regional Differences in Physical Fitness of Geological University Students
The intention of this study is to investigate the distribution of physical fitness of the geographical students. The indicators among freshmen at a Chinese geological university and compare their fitness level...
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Article
Open AccessEffectiveness and safety of finerenone in Chinese CKD patients without diabetes: a retrospective, real-world study
Finerenone, a non-steroidal mineralocorticoid receptor antagonist, has previously demonstrated its efficacy and safety in chronic kidney disease (CKD) associated with diabetes mellitus. Given its therapeutic p...
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Article
Are the facet joint parameters risk factors for cage subsidence after TLIF in patients with lumbar degenerative spondylolisthesis?
To assess whether preoperative facet joint parameters in patients with degenerative lumbar spondylolisthesis (DS) are risk factors for cage subsidence (CS) following transforaminal lumbar interbody fusion (TLIF).
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Article
Open AccessO-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancer
Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle and cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to CDK4/6 inhi...
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Article
TOCOL: improving contextual representation of pre-trained language models via token-level contrastive learning
Self-attention, which allows transformers to capture deep bidirectional contexts, plays a vital role in BERT-like pre-trained language models. However, the maximum likelihood pre-training objective of BERT may...
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Article
Temporal relationship between hepatic steatosis and blood pressure elevation and the mediation effect in the development of cardiovascular disease
The temporal relationship between non-alcoholic fatty liver disease (NAFLD) and hypertension remains highly controversial, with ongoing debates on whether NAFLD induces hypertension or vice versa. We employed ...
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Article
Open AccessComplement C3a/C3aR and C5a/C5aR deposits accelerate the progression of advanced IgA nephropathy to end-stage renal disease
IgA nephropathy (IgAN) is still one of the leading causes of end-stage kidney disease (ESRD), and complement system activation is a key to the pathogenesis of IgAN. The role of complement C3a/C3aR and C5a/C5aR...
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Article
Open AccessRailway track settlement patterns and control measures for multi-tunnel construction underneath a station track group: a case study
This paper is based on the proximity engineering project of the Baishiyi tunnel group passing under the Chongqing West Station track group. Considering the train load and the spatial relationship of the tunnel...
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Article
Raised Bed Planting Pattern Improves Root Growth and Nitrogen use Efficiency of Post-Rice Wheat
Conventional puddling (rice season) and flat planting (wheat season) deteriorate soil properties and induce high mechanical impedance of roots, while increasing nitrogen (N) loss, affecting the normal developm...
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Article
Development of in-situ nanofibrillated poly(butylene succinate)/polytetrafluoroethylene composites with elevated rheology, crystallization, and foaming performance
Herein, the nanofibrillated poly(butylene succinate)/polytetrafluoroethylene (PBS/PTFE) composites were prepared. The relaxation time was prolonged by PTFE fibrils, resulting in an enhancement in storage modul...
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Article
Modeling of temperature distribution and clad geometry of the molten pool during laser cladding of CoCrCuFeNi alloys
This work simulated a modified three-dimensional single-track finite element model and a temperature discrimination mechanism in order to investigate the variation of temperature field in stainless steel and t...
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Article
Open AccessImmunogenicity evaluation of primary polio vaccination schedule with inactivated poliovirus vaccines and bivalent oral poliovirus vaccine
To assess the immunogenicity of the current primary polio vaccination schedule in China and compare it with alternative schedules using Sabin or Salk-strain IPV (sIPV, wIPV).
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Article
Low-temperature Leidenfrost-like jum** of sessile droplets on microstructured surfaces
The Leidenfrost effect—the levitation and hovering of liquid droplets on hot solid surfaces—generally requires a sufficiently high substrate temperature to activate liquid vaporization. Here we report the modu...
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Article
Open AccessCorrection: Chromosome-level genome provides insights into environmental adaptability and innate immunity in the common dolphin (Delphinus delphis)
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Article
Open AccessUnraveling the interplay of ferroptosis and immune dysregulation in diabetic kidney disease: a comprehensive molecular analysis
Diabetic kidney disease (DKD) is a primary microvascular complication of diabetes with limited therapeutic effects. Delving into the pathogenic mechanisms of DKD and identifying new therapeutic targets is cruc...
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Article
Open AccessChromosome-level genome provides insights into environmental adaptability and innate immunity in the common dolphin (Delphinus delphis)
The common dolphin (Delphinus delphis) is widely distributed worldwide and well adapted to various habitats. Animal genomes store clues about their pasts, and can reveal the genes underlying their evolutionary su...
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Article
Open AccessExciton engineering of 2D Ruddlesden–Popper perovskites by synergistically tuning the intra and interlayer structures
Designing two-dimensional halide perovskites for high-performance optoelectronic applications requires deep understanding of the structure-property relationship that governs their excitonic behaviors. However,...
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Article
Chiral assembly of nanoparticles in functional inorganic materials
Chirality is prevalent in nature, offering unique inspirations for building functional inorganic materials. Within these intricate chiral materials, the assembly of nanoparticles as fundamental building blocks...
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Article
Open AccessA dual diffusion model enables 3D molecule generation and lead optimization based on target pockets
Structure-based generative chemistry is essential in computer-aided drug discovery by exploring a vast chemical space to design ligands with high binding affinity for targets. However, traditional in silico me...
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Article
Open AccessFrost protection mechanism based on rubber airbag interlayered composite lining system for cold-region tunnels
To solve the problem of freezing damage in cold-region tunnels, this study proposed a rubber airbag interlayered composite lining system, and tested its performance of buffering, pressure adjustment, waterproo...
