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Article
Open AccessO-GlcNAcylation of MITF regulates its activity and CDK4/6 inhibitor resistance in breast cancer
Cyclin-dependent kinases 4 and 6 (CDK4/6) play a pivotal role in cell cycle and cancer development. Targeting CDK4/6 has demonstrated promising effects against breast cancer. However, resistance to CDK4/6 inhi...
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Article
Open AccessPGC-1α repression dysregulates lipid metabolism and induces lipid droplet accumulation in the retinal pigment epithelium
Drusen, the yellow deposits under the retina, are composed of lipids and proteins, and represent a hallmark of age-related macular degeneration (AMD). Lipid droplets are also reported in the retinal pigment ep...
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Article
Open AccessEndosulfan residues and farmers’ replacement behaviors of endosulfan in the north-west inland cotton region
We assessed the situation of endosulfan residues in cotton fields after the endosulfan ban came into effect and the current knowledge, attitude, and practice (KAP) of cotton farmers on the phase-out of endosul...
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Article
Open AccessAnomalous hydrodynamics effective actions from holography
We derive an effective action for charged plasmas with an anomalous (abelian) global current charge current using holography. The holographic description is captured by the dynamics of an Einstein-Maxwell-Cher...
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Article
Open AccessPartial reduction and cosmology at defect brane
Partial reduction is a Karch-Randall reduction for only part of the AdS region between finite tension brane and zero tension brane. This is interesting in AdS/BCFT where the AdS bulk contains a defect brane. W...
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Article
Open AccessMolecular characterization of carbapenem-resistant Klebsiella pneumoniae isolates with focus on antimicrobial resistance
The enhancing incidence of carbapenem-resistant Klebsiella pneumoniae (CRKP)-mediated infections in Mengchao Hepatobiliary Hospital of Fujian Medical University in 2017 is the motivation behind this investigation...
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Article
LncRNA PlncRNA-1 overexpression inhibits the growth of breast cancer by upregulating TGF-β1 and downregulating PHGDH
To investigate the role of lncRNA PlncRNA-1 in the pathogenesis of breast cancer.
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Article
Open AccessSelf-Assembly Assisted Fabrication of Dextran-Based Nanohydrogels with Reduction-Cleavable Junctions for Applications as Efficient Drug Delivery Systems
In order to overcome the key challenge in improving both fabrication efficiency and their drug delivery capability of anti-cancer drug delivery systems (ACDDS), here polyacrylic acid (PAA) grafted dextran (Dex...
