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Open AccessCorrection to: Optical map** of human embryonic stem cell-derived cardiomyocyte graft electrical activity in injured hearts
An amendment to this paper has been published and can be accessed via the original article.
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Article
Open AccessSex impacts cardiac function and the proteome response to thyroid hormone in aged mice
Sex and age have substantial influence on thyroid function. Sex influences the risk and clinical expression of thyroid disorders (TDs), with age a proposed trigger for the development of TDs. Cardiac function ...
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Article
Open AccessOptical map** of human embryonic stem cell-derived cardiomyocyte graft electrical activity in injured hearts
Human embryonic stem cell-derived cardiomyocytes (hESC-CMs) show tremendous promise for cardiac regeneration, but the successful development of hESC-CM-based therapies requires improved tools to investigate th...
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Article
β-Arrestin 2 mediates arginine vasopressin-induced IL-6 induction via the ERK1/2-NF-κB signal pathway in murine hearts
Evidence to date suggests that β-arrestins act beyond their role as adapter proteins. Arginine vasopressin (AVP) may be a factor in inflammation and fibrosis in the pathogenesis of heart failure. In the presen...
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Protocol
Methods for Assessing the Electromechanical Integration of Human Pluripotent Stem Cell-Derived Cardiomyocyte Grafts
Cardiomyocytes derived from human pluripotent stem cells show tremendous promise for the replacement of myocardium and contractile function lost to infarction. However, until recently, no methods were availabl...
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Article
VEGFA SNPs and transcriptional factor binding sites associated with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau
Mountain sickness (MS) occurs among humans visiting or inhabiting high altitude environments. We conducted genetic analyses of seven single nucleotide polymorphisms (SNPs) in the promoter region of VEGFA gene ...
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Article
Human ES-cell-derived cardiomyocytes electrically couple and suppress arrhythmias in injured hearts
A guinea-pig model of cardiac injury is used to show that human embryonic stem-cell-derived cardiomyocyte grafts can electrically integrate into the injured heart, improving mechanical function and reducing sp...
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Article
AKT3, ANGPTL4, eNOS3, and VEGFA associations with high altitude sickness in Han and Tibetan Chinese at the Qinghai-Tibetan Plateau
Mountain sickness (MS) occurs among humans visiting or inhabiting high altitude environments. We conducted genetic analyses of the AKT3, ANGPTL4, eNOS3 and VEGFA genes in lowland (Han) and highland (Tibetan) C...
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Article
Proteomic analysis of mitochondrial proteins in cardiomyocytes from rats subjected to intermittent hypoxia
Intermittent hypoxia (IH) markedly enhances cardiac tolerance against ischemia/reperfusion injury, but its mechanism and molecular basis remain unclear. For exploring the expression of mitochondrial proteins i...
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Protocol
Methods for the Derivation and Use of Cardiomyocytes from Human Pluripotent Stem Cells
The availability of human cardiomyocytes derived from embryonic stem cells (ESCs) has generated considerable excitement, as these cells are an excellent model system for studying myocardial development and ma...
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Article
Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury
To investigate the role of inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) in the cardioprotection of intermittent hypoxia (IH) against ischemia/reperfusion (I/R) injury.
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Article
Perspectives on the metallic interconnects for solid oxide fuel cells
The various stages and progress in the development of interconnect materials for solid oxide fuel cells (SOFCs) over the last two decades are reviewed. The criteria for the application of materials as intercon...
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Article
Postnatal development in intermittent hypoxia enhances resistance to myocardial ischemia/reperfusion in male rats
To assess the tolerance of rats that developed from birth in intermittent hypoxia (IH) to myocardial ischemia and reperfusion, we set up a reproducible model in our laboratory. IH rats were raised 60 days from...
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Article
Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2/Bax expression
Intermittent hypoxia has been shown to provide myocardial protection against ishemia/reperfusion-induced injury. Cardiac myocyte loss through apoptosis has been reported in ischemia/reperfusion injury. Our aim...
