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Article
CRF regulates pain sensation by enhancement of corticoaccumbal excitatory synaptic transmission
Both peripheral and central corticotropin-releasing factor (CRF) systems have been implicated in regulating pain sensation. However, compared with the peripheral, the mechanisms underlying central CRF system i...
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Article
Open AccessA common neuronal ensemble in nucleus accumbens regulates pain-like behaviour and sleep
A comorbidity of chronic pain is sleep disturbance. Here, we identify a dual-functional ensemble that regulates both pain-like behaviour induced by chronic constrictive injury or complete Freund’s adjuvant, an...
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Article
Open AccessKCNQ Channels in the Mesolimbic Reward Circuit Regulate Nociception in Chronic Pain in Mice
Mesocorticolimbic dopaminergic (DA) neurons have been implicated in regulating nociception in chronic pain, yet the mechanisms are barely understood. Here, we found that chronic constructive injury (CCI) in mi...
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Article
Mesocortical BDNF signaling mediates antidepressive-like effects of lithium
Lithium has been used to treat major depressive disorder, yet the neural circuit mechanisms underlying this therapeutic effect remain unknown. Here, we demonstrated that the ventral tegmental area (VTA) dopami...
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Article
Inducible nitric oxide synthase contributes to intermittent hypoxia against ischemia/reperfusion injury
To investigate the role of inducible nitric oxide synthase (iNOS)-derived nitric oxide (NO) in the cardioprotection of intermittent hypoxia (IH) against ischemia/reperfusion (I/R) injury.
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Article
Postnatal development in intermittent hypoxia enhances resistance to myocardial ischemia/reperfusion in male rats
To assess the tolerance of rats that developed from birth in intermittent hypoxia (IH) to myocardial ischemia and reperfusion, we set up a reproducible model in our laboratory. IH rats were raised 60 days from...
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Article
Intermittent hypoxia attenuates ischemia/reperfusion induced apoptosis in cardiac myocytes via regulating Bcl-2/Bax expression
Intermittent hypoxia has been shown to provide myocardial protection against ishemia/reperfusion-induced injury. Cardiac myocyte loss through apoptosis has been reported in ischemia/reperfusion injury. Our aim...
