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Article
Open AccessProfound parental bias associated with chromosome 14 acquired uniparental disomy indicates targeting of an imprinted locus
Acquired uniparental disomy (aUPD) is a common finding in myeloid malignancies and typically acts to convert a somatically acquired heterozygous mutation to homozygosity. We sought to identify the target of ch...
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Article
Erratum: Rapid memory T-cell reconstitution recapitulating CD45RA-depleted haploidentical transplant graft content in patients with hematologic malignancies
Correction to: Bone Marrow Transplantation (2015) 50, 968–977; doi:10.1038/bmt.2014.324; published online 9 February 2015 Since the publication of this article, a comprehensive review of enrolled subjects by i...
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Article
Rapid memory T-cell reconstitution recapitulating CD45RA-depleted haploidentical transplant graft content in patients with hematologic malignancies
T-cell depletion of an HLA-haploidentical graft is often used to prevent GVHD, but the procedure may lead to increased graft failure, relapse and infections due to delayed immune recovery. We hypothesized that...
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Article
Open AccessChimeric antigen receptor-redirected CD45RA-negative T cells have potent antileukemia and pathogen memory response without graft-versus-host activity
Chimeric antigen receptor (CAR)-redirected cellular therapy is an attractive modality for cancer treatment. We hypothesized that allogeneic CAR-engineered CD45RA-negative T cells can control cancer and infecti...
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Article
Open AccessRisk-adapted donor lymphocyte infusion based on chimerism and donor source in pediatric leukemia
Donor lymphocyte infusion (DLI) is commonly used to treat leukemia relapse following stem cell transplantation. In florid relapse, however, the efficacy of DLI is limited with substantial risk of severe graft-...
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Article
A phase I/II study of CY and topotecan in patients with high-risk malignancies undergoing autologous hematopoietic cell transplantation: the St Jude long-term follow-up
Fifty-eight consecutive children with high-risk malignancies were treated with CY, and targeted topotecan followed by autologous hematopoietic cell transplantation (AHCT) in a phase I/II Institutional Review B...
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Article
ETV6-RUNX1-positive childhood acute lymphoblastic leukemia: improved outcome with contemporary therapy
ETV6-RUNX1 fusion is the most common genetic aberration in childhood acute lymphoblastic leukemia (ALL). To evaluate whether outcomes for this drug-sensitive leukemia are improved by contemporary risk-directed th...
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Article
Effects of activating NK cell receptor expression and NK cell reconstitution on the outcomes of unrelated donor hematopoietic cell transplantation for hematologic malignancies
Inhibitory NK cell receptors are recognized as important determinants of NK cell activity in hematopoietic cell transplantation (HCT). The role of activating receptors and their acquisition after HCT is less c...
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Open AccessReply: Missing ligand model in autologous stem cell transplantation
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Article
Open AccessInhibitory KIR–HLA receptor–ligand mismatch in autologous haematopoietic stem cell transplantation for solid tumour and lymphoma
Genes that encode killer Ig-like receptors (KIRs) and their HLA class I ligands segregate independently; thus, some individuals may express an inhibitory KIR gene but not its cognate ligand. We hypothesised th...
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Article
Encephalopathy in pediatric patients after allogeneic hematopoietic stem cell transplantation is associated with a poor prognosis
Encephalopathy is a poorly characterized complication of hematopoietic stem cell transplantation (HSCT). No comprehensive report of encephalopathy exists for children, and the literature contains only a few fo...
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Article
Effective donor lymphohematopoietic reconstitution after haploidentical CD34+-selected hematopoietic stem cell transplantation in children with refractory severe aplastic anemia
Peritransplant toxicity and a delay in effective immune reconstitution have limited the utility of alternate donor transplantation for children with refractory severe aplastic anemia. We have assessed the effe...
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Article
Allogeneic bone marrow transplantation for children with histiocytic disorders: use of TBI and omission of etoposide in the conditioning regimen
The histiocytoses are rare disorders of antigen-processing phagocytic or antigen-presenting cells. Allogeneic bone marrow transplantation (BMT) can be curative of these disorders. We report a series of five ch...
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Article
Open AccessTumour cell contamination of autologous stem cells grafts in high-risk neuroblastoma: the good news?
We analysed the effect of graft-contaminating tumour cells on the long-term survival of 24 patients with high-risk neuroblastoma and found that patients whose grafts contained detectable neuroblastoma cells ha...
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Article
Atypical Kawasaki Disease- Experience in Hong Kong
Introduction: Infants with atypical Kawasaki Disease always posed a diagnostic difficulty to cardiologist and literature has suggested that infants with Kawasaki Disease had a higher complication rate. A retro...
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Article
Ruptured adrenocortical carcinoma as a cause of paediatric acute abdomen
Adrenocortical carcinoma (ACC) is rare in children. Its presentation is usually related to hormonal activity of the tumour. We report a case of childhood ACC that presented as an acute abdomen due to tumour ru...
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Article
Allogeneic BMT for infantile acute leukemia: what is the optimal conditioning regimen?
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Article
Allogeneic bone marrow transplantation for infants with acute leukemia or myelodysplastic syndrome
The objective of this study is to investigate the outcome of children 24 months of age or younger (infants) at the time of allogeneic bone marrow transplantation (BMT) for acute leukemia or myelodysplasia. We ...
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Article
Allogeneic bone marrow transplantation in children failing prior autologous bone marrow transplantation
Twenty-three children with de novo acute myelogenous leukemia (AML) (n= 20), secondary AML (n = 1), or non-Hodgkin's lymphoma (NHL) (n = 2) underwent allogeneic bone marrow transplantation (alloBMT) for graft fai...
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Article
Second malignancy after treatment of childhood acute myeloid leukemia
To investigate the cumulative incidence of second malignancy and the competing risk of death due to any other cause in patients who were treated for childhood acute myeloid leukemia (AML), we analyzed the outc...
