-
Article
Open AccessGenetic markers associated with abstinence length in alcohol-dependent subjects treated with acamprosate
Acamprosate supports abstinence in some alcohol-dependent subjects, yet predictors of response are unknown. To identify response biomarkers, we investigated associations of abstinence length with polymorphisms...
-
Article
Open AccessClinical Characteristics of Ovarian Cancer Classified by BRCA1, BRCA2 and RAD51C Status
We evaluated homologous recombination deficient (HRD) phenotypes in epithelial ovarian cancer (EOC) considering BRCA1, BRCA2 and RAD51C in a large well-annotated patient set. We evaluated EOC patients for germlin...
-
Article
Effects of late gestational high-fat diet on body weight, metabolic regulation and adipokine expression in offspring
Gestational exposures such as dietary changes can alter offspring phenotype through epigenetic modifications and promote increased risk for specific diseases, such as metabolic syndrome. We hypothesized that h...
-
Article
Open AccessErratum: Validating genetic risk associations for ovarian cancer through the International Ovarian Cancer Association Consortium
Correction to: British Journal of Cancer (2009) 100, 412–420. doi:10.1038/sj.bjc.6604820 www.bjcancer.com Upon publication of this paper in Volume 100, one of the co-author's names was incorrectly stated – Jul...
-
Article
Open AccessCell cycle genes and ovarian cancer susceptibility: a tagSNP analysis
Dysregulation of the cell cycle is a hallmark of many cancers including ovarian cancer, a leading cause of gynaecologic cancer mortality worldwide.
-
Article
Encephalopathy in pediatric patients after allogeneic hematopoietic stem cell transplantation is associated with a poor prognosis
Encephalopathy is a poorly characterized complication of hematopoietic stem cell transplantation (HSCT). No comprehensive report of encephalopathy exists for children, and the literature contains only a few fo...
-
Article
Effective donor lymphohematopoietic reconstitution after haploidentical CD34+-selected hematopoietic stem cell transplantation in children with refractory severe aplastic anemia
Peritransplant toxicity and a delay in effective immune reconstitution have limited the utility of alternate donor transplantation for children with refractory severe aplastic anemia. We have assessed the effe...
-
Article
Allogeneic bone marrow transplantation for children with histiocytic disorders: use of TBI and omission of etoposide in the conditioning regimen
The histiocytoses are rare disorders of antigen-processing phagocytic or antigen-presenting cells. Allogeneic bone marrow transplantation (BMT) can be curative of these disorders. We report a series of five ch...
-
Article
Functional correction of T cells derived from patients with the Wiskott–Aldrich syndrome (WAS) by transduction with an oncoretroviral vector encoding the WAS protein
T-cell dysfunction is thought to be central to the immunodeficiency state seen in patients with the Wiskott–Aldrich syndrome (WAS). Aspects of the WAS phenotype have been corrected in other cell types on intro...
-
Article
Circadian variation in Cushing’s disease and pseudo-Cushing states by analysis of F and ACTH pulsatility
Distinguishing pituitary-dependent Cushing’s disease from pseudo-Cushing’s states can present a diagnostic challenge. Although many studies potentially discriminate between the 2, only the dexamethasone-suppre...
-
Article
35th Annual Meeting of the European Association for the Study of Diabetes
-
Article
Insulitis and mechanisms of disease resistance: studies in an animal model of insulin dependent diabetes mellitus
Insulin dependent diabetes mellitus (IDDM) is an autoimmune disease characterised by extreme insulin deficiency due to an overall decrease in the mass of properly functioning β-cells. This reduction occurs as...
-
Chapter
Nitric Oxide Rather than Superoxide or Peroxynitrite Inhibits Insulin Secretion and Causes DNA Damage in HIT-T15 Cells
We have previously demonstrated that treatment of rat islets of Langerhans with the nitric oxide donors 3-morpholinosydnonimine (SIN-1) and S-nitrosoglutathione (GSNO) inhibits insulin secretion and increases ...
-
Article
The inducible nitric oxide synthase gene, Nos2, maps to mouse Chromosome 11
-
Article
Interleukin-1β effects on cyclic GMP and cyclic AMP in cultured rat islets of Langerhans — arginine — dependence and relationship to insulin secretion
When islets were cultured with interleukin-1β (1 or 100 pmol/l) for 12 h in arginine-containing medium, cyclic GMP levels were increased 1.6- and 4.5-fold respectively. The arginine analogue, N-ω-nitro-l-arginine...
-
Article
Rostrocaudal variation of fiber type composition in rat intercostal muscles
We used the histochemical stain for ATPase to compare the fiber-type composition of rat internal and external intercostal muscles from thoracic (T) segments 2–5, 8, and 11. At each level, type II fibers were m...
-
Chapter
Activated Oncogenes in Burkitt’s Lymphoma
Burkitt’s lymphoma (BL) was recognized more than 25 years ago as a distinct pathoclinical entitity with peculiar epidemiological characteristics. The tumor, which occurs with a high incidence in certain areas ...
