Bladder Tumors:
Molecular Aspects and Clinical Management
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Vinata B. Lokeshwar
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Article
Open AccessTargeting hyaluronic acid synthase-3 (HAS3) for the treatment of advanced renal cell carcinoma
Hyaluronic acid (HA) promotes cancer metastasis; however, the currently approved treatments do not target HA. Metastatic renal carcinoma (mRCC) is an incurable disease. Sorafenib (SF) is a modestly effective a...
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Article
Open AccessMolecular targeting of renal cell carcinoma by an oral combination
The 5-year survival rate of patients with metastatic renal cell carcinoma (mRCC) is <12% due to treatment failure. Therapeutic strategies that overcome resistance to modestly effective drugs for mRCC, such as ...
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Article
Open AccessHyaluronic acid family in bladder cancer: potential prognostic biomarkers and therapeutic targets
Molecular markers of clinical outcome may aid in designing targeted treatments for bladder cancer. However, only a few bladder cancer biomarkers have been examined as therapeutic targets.
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Reference Work Entry In depth
Hyaluronidase
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Reference Work Entry In depth
Molecular Biomarkers and Treatments for Renal Cell Carcinoma
Recent advances in the biological understanding of renal cell carcinoma (RCC) have led to the identification of several molecular biomarkers with prognostic and therapeutic value. Clinical trials have proven t...
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Living Reference Work Entry In depth
Hyaluronidase
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Living Reference Work Entry In depth
Molecular Biomarkers and Treatments for Renal Cell Carcinoma
Recent advances in the biological understanding of renal cell carcinoma (RCC) have led to the identification of several molecular biomarkers with prognostic and therapeutic value. Clinical trials have proven t...
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Article
Age—an independent prognostic factor of clinical outcome in renal malignancies: results of a large study over two decades
Age has been linked to outcome in renal cancer patients, but mainly in North American cohorts. In this study, we hypothesized that age is correlated with metastasis and cancer-specific survival in a German coh...
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Book
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Reference Work Entry In depth
Hyaluronidase
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Chapter
Bladder Carcinogenesis and Molecular Pathways
Bladder cancer is primarily a “carcinogenesis driven” cancer. Exposure to carcinogens such as polycyclic aromatic hydrocarbons (PAH), aromatic amines (AA), and nitrosamines through cigarette smoking, occupatio...
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Reference Work Entry In depth
Hyaluronidase
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Article
An orally active Amazonian plant extract (BIRM) inhibits prostate cancer growth and metastasis
Poor efficacy of conventional chemotherapeutic drugs against metastatic hormone-refractory prostate cancer (CaP) drives patients to try "alternative medicine". The antitumor activity of one such agent, "BIRM" ...
