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Age—an independent prognostic factor of clinical outcome in renal malignancies: results of a large study over two decades

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Abstract

Purpose

Age has been linked to outcome in renal cancer patients, but mainly in North American cohorts. In this study, we hypothesized that age is correlated with metastasis and cancer-specific survival in a German cohort regardless of types of treatments.

Methods

A total of 1,538 patients treated for renal malignancies between 1991 and 2010 were evaluated. Mean age and median age are 61.9 ± 11.6 and 62.6 years. Clinicopathologic [tumor type, size, grade, stage and treatment (surgery, chemotherapy, radiation, immunotherapy)] and outcome parameters (metastasis and survival) were examined for an association with age using logistic regression and Cox proportional hazard model, and Kaplan–Meier plots.

Results

Age was associated with stage, metastasis, treatment, cancer-specific and overall mortality (p < 0.01). The metastasis-free and cancer-free survival rates for patients >63 years were lower than those for patients ≤63 years (p < 0.0001). In a multivariate analysis, age was an independent prognostic factor of metastasis, cancer-specific and overall mortality (p < 0.0001) even when data were stratified in different decades and treatment was included as one of the parameters. Patients >63 years of age had 29–35 % higher risk of metastasis and cancer-specific mortality than younger patients. Median metastasis-free and cancer-specific survival for patients >63 years of age (months: 84.4; 70.3) was ~50 % shorter than in patients ≤63 years (months: 151; 144.6).

Conclusions

This large study shows that, despite advances in surgical and non-surgical treatment modalities over the two decades, age is an independent prognostic indicator of metastasis and cancer-specific mortality in renal cancer patients. Patients >63 years have ~30 % increased risk for metastasis and ~50 % shorter cancer-specific survival.

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Acknowledgments

Support in terms of collection and management of the data was provided by the Clinical Cancer Registry of the Medical School Hannover. Marie C. Hupe was supported by fellowship from the Hannover Biomedical Research School, StrucMed Program. She was a fellow of the International Academy of Life Sciences, Biomedical Exchange Program in Dr. Vinata Lokeshwar’s laboratory.

Conflict of interest

The authors declare that they have no conflict of interest.

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Authors and Affiliations

  1. Department of Urology and Urologic Oncology, Hannover Medical School (OE 6240), Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Marie C. Hupe, Axel S. Merseburger, Hendrik Eggers, Hendrik Rott, Markus A. Kuczyk & Thomas R. Herrmann

  2. Department of Urology, University of Miami Miller School of Medicine, P.O. Box 016960, Miami, FL, 33101, USA

    Marie C. Hupe

  3. Departments of Urology (M-800), Cell Biology, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, P.O. Box 016960, Miami, FL, 33101, USA

    Vinata B. Lokeshwar

  4. Clinical Cancer Registry, Hannover Medical School (OE 8850), Cooperative Cancer Centre, Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Gerd Wegener

  5. Department of Pathology, Hannover Medical School (OE 5110), Carl-Neuberg-Str. 1, 30625, Hannover, Germany

    Mahmoud Abbas

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  1. Marie C. Hupe
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  2. Axel S. Merseburger
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Corresponding author

Correspondence to Vinata B. Lokeshwar.

Additional information

Marie C. Hupe and Axel S. Merseburger have contributed equally and are joint first authors.

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Hupe, M.C., Merseburger, A.S., Lokeshwar, V.B. et al. Age—an independent prognostic factor of clinical outcome in renal malignancies: results of a large study over two decades. World J Urol 32, 115–121 (2014). https://doi.org/10.1007/s00345-013-1164-6

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  • DOI: https://doi.org/10.1007/s00345-013-1164-6

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