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  1. Article

    Open Access

    The validation status of blood biomarkers of amyloid and phospho-tau assessed with the 5-phase development framework for AD biomarkers

    The development of blood biomarkers that reflect Alzheimer’s disease (AD) pathophysiology (phosphorylated tau and amyloid-β) has offered potential as scalable tests for dementia differential diagnosis and earl...

    N. J. Ashton, A. Leuzy, T. K. Karikari… in European Journal of Nuclear Medicine and M… (2021)

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  2. Article

    Open Access

    2020 update on the clinical validity of cerebrospinal fluid amyloid, tau, and phospho-tau as biomarkers for Alzheimer’s disease in the context of a structured 5-phase development framework

    In the last decade, the research community has focused on defining reliable biomarkers for the early detection of Alzheimer’s disease (AD) pathology. In 2017, the Geneva AD Biomarker Roadmap Initiative adapted...

    A. Leuzy, N. J. Ashton, N. Mattsson-Carlgren… in European Journal of Nuclear Medicine and M… (2021)

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  3. Article

    Open Access

    Clinical validity of increased cortical uptake of [18F]flortaucipir on PET as a biomarker for Alzheimer’s disease in the context of a structured 5-phase biomarker development framework

    In 2017, the Geneva Alzheimer’s disease (AD) Biomarker Roadmap initiative adapted the framework of the systematic validation of oncological diagnostic biomarkers to AD biomarkers, with the aim to accelerate th...

    E. E. Wolters, A. Dodich, M. Boccardi… in European Journal of Nuclear Medicine and M… (2021)

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  4. No Access

    Article

    A kinetics-based approach to amyloid PET semi-quantification

    To develop and validate a semi-quantification method (time-delayed ratio, TDr) applied to amyloid PET scans, based on tracer kinetics information.

    A. Chincarini, E. Peira, M. Corosu… in European Journal of Nuclear Medicine and M… (2020)

  5. No Access

    Article

    Source-Based Morphometry Multivariate Approach to Analyze [123I]FP-CIT SPECT Imaging

    [123I]FP-CIT (DaTSCAN®) single-photon emission computed tomography (SPECT) imaging is widely used to study neurodegenerative parkinsonism, by measuring presynaptic dopamine transporter (DAT) in striatal regions. ...

    Enrico Premi, V. D. Calhoun, V. Garibotto, R. Turrone… in Molecular Imaging and Biology (2017)

  6. No Access

    Article

    Severe early basal ganglia hypometabolism in neurodegeneration with brain iron accumulation

    Ismini C. Mainta, C. Tabouret-Viaud… in European Journal of Nuclear Medicine and M… (2016)

  7. Article

    Molecular neuroimaging with PET/MRI

    Hybrid PET/MRI is a recently developed technique, which is attracting growing interest among the medical community owing to its potential clinical and research applications. PET/MRI is of special interest for ...

    V. Garibotto, S. Förster, S. Haller, M. I. Vargas… in Clinical and Translational Imaging (2013)

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  8. No Access

    Chapter

    Brain Tumors

    Because of its high soft-tissue contrast, MRI is the method of choice for the assessment of brain tumors. Conventional MRI sequences provide excellent visualization of the lesions, but still have limitations f...

    V. Garibotto, A. Baskin, M. Essler, S. Foerster… in Atlas of PET/MR Imaging in Oncology (2013)

  9. No Access

    Article

    Education and occupation provide reserve in both ApoE ε4 carrier and noncarrier patients with probable Alzheimer’s disease

    According to the reserve hypothesis, a high educational/occupational attainment can modulate Alzheimer’s disease (AD) clinical expression. The impact of the Apolipoprotein E (ApoE) ε4 allele on the reserve mechan...

    V. Garibotto, B. Borroni, S. Sorbi, S. F. Cappa, A. Padovani… in Neurological Sciences (2012)