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Article
Open AccessDiagnostic accuracy of research criteria for prodromal frontotemporal dementia
The Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia (FTD), termed mild cognitive and/or behavioral and/or motor impairment ...
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Article
Open AccessHome-based transcranial alternating current stimulation (tACS) in Alzheimer’s disease: rationale and study design
Gamma (γ) brain oscillations are dysregulated in Alzheimer’s disease (AD) and can be modulated using transcranial alternating stimulation (tACS). In the present paper, we describe the rationale and design of a...
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Article
Imaging features and ultraearly hematoma growth in intracerebral hemorrhage associated with COVID-19
Intracerebral hemorrhage (ICH) is an uncommon but deadly event in patients with COVID-19 and its imaging features remain poorly characterized. We aimed to describe the clinical and imaging features of COVID-19...
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Article
Open AccessClinical outcome of neurological patients with COVID-19: the impact of healthcare organization improvement between waves
The aim of this study is to evaluate the differences in clinical presentations and the impact of healthcare organization on outcomes of neurological COVID-19 patients admitted during the first and second pande...
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Article
Open AccessSARS-CoV-2 infection and acute ischemic stroke in Lombardy, Italy
To characterize patients with acute ischemic stroke related to SARS-CoV-2 infection and assess the classification performance of clinical and laboratory parameters in predicting in-hospital outcome of these pa...
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Article
Open AccessArterial tortuosity syndrome causing recurrent transient ischemic attacks in young adult: a case report
Arterial Tortuosity Syndrome (ATS) is a rare autosomal recessive disorder characterized by elongated and tortuous arteries. Although ATS showed a significant clinical and pathophysiological overlap with other ...
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Article
Impact of SARS-CoV-2 on reperfusion therapies for acute ischemic stroke in Lombardy, Italy: the STROKOVID network
Whether and how SARS-CoV-2 outbreak affected in-hospital acute stroke care system is still matter of debate. In the setting of the STROKOVID network, a collaborative project between the ten centers designed as...
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Article
Open AccessLanguage training for oral and written naming impairment in primary progressive aphasia: a review
Primary progressive aphasia (PPA) is a neurodegenerative disorder characterized by a gradual, insidious and progressive loss of language abilities, with naming difficulties being an early and persistent impair...
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Article
Open AccessEnhanced dynamic functional connectivity (whole-brain chronnectome) in chess experts
Multidisciplinary approaches have demonstrated that the brain is potentially modulated by the long-term acquisition and practice of specific skills. Chess playing can be considered a paradigm for sha** brain...
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Article
Extrastriatal dopaminergic and serotonergic pathways in Parkinson’s disease and in dementia with Lewy bodies: a 123I-FP-CIT SPECT study
The aim of the study was to evaluate extrastriatal dopaminergic and serotonergic pathways in patients with Parkinson’s disease (PD) and dementia with Lewy bodies (DLB) using 123I-FP-CIT SPECT imaging.
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Article
Open AccessIntravenous fibrinolysis plus endovascular thrombectomy versus direct endovascular thrombectomy for anterior circulation acute ischemic stroke: clinical and infarct volume results
endovascular therapy (ET) is the standard of care for anterior circulation acute ischemic stroke (AIS) caused by large vessel occlusion (LVO). The role of adjunctive intravenous thrombolysis (IVT) in these pat...
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Article
Open AccessModulation of long-term potentiation-like cortical plasticity in the healthy brain with low frequency-pulsed electromagnetic fields
Non-depolarizing magnetic fields, like low frequency-pulsed electromagnetic fields (LF-PEMFs) have shown the ability to modulate living structures, principally by influencing synaptic activity and ion channels...
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Article
Neuroanatomical Correlates of Transcranial Magnetic Stimulation in Presymptomatic Granulin Mutation Carriers
Frontotemporal dementia (FTD) is characterized by behavioural and language impairment, accompanied by atrophic changes in fronto-temporo-insular cortices. In the presymptomatic phases of genetic FTD, subtle or...
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Article
Source-Based Morphometry Multivariate Approach to Analyze [123I]FP-CIT SPECT Imaging
[123I]FP-CIT (DaTSCAN®) single-photon emission computed tomography (SPECT) imaging is widely used to study neurodegenerative parkinsonism, by measuring presynaptic dopamine transporter (DAT) in striatal regions. ...
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Article
Open AccessAltered brain metabolic connectivity at multiscale level in early Parkinson’s disease
To explore the effects of PD pathology on brain connectivity, we characterized with an emergent computational approach the brain metabolic connectome using [18F]FDG-PET in early idiopathic PD patients. We appl...
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Article
Leukoaraiosis is a predictor of futile recanalization in acute ischemic stroke
Futile recanalization occurs when successful recanalization fails to improve clinical outcome in acute ischemic stroke patients. Predictors of futile recanalization are still debated and may help in selecting ...
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Article
Grey Matter Density Predicts the Improvement of Naming Abilities After tDCS Intervention in Agrammatic Variant of Primary Progressive Aphasia
Agrammatic variant primary progressive aphasia is a neurodegenerative disorder specifically characterized by language deficits. A recent study has demonstrated a beneficial effect of transcranial direct curren...
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Article
Open AccessFrontotemporal dementia and language networks: cortical thickness reduction is driven by dyslexia susceptibility genes
Variations within genes associated with dyslexia result in a language network vulnerability, and in patients with Frontotemporal Dementia (FTD), language disturbances represent a disease core feature. Here we ...
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Article
Endovascular mechanical thrombectomy in basilar artery occlusion: variables affecting recanalization and outcome
Ischemic stroke due to basilar artery occlusion (BAO) is frequently associated with a poor prognosis. To date the most effective therapeutic approach has not been established and little is known about the pred...
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Article
Phenotypic heterogeneity of Niemann–Pick disease type C in monozygotic twins
We report the case of Niemann–Pick disease type C with extensive phenotypic heterogeneity in two monozygotic twins. One of the twins presented with a history of obsessive–compulsive disorder and slowly progres...
