-
Article
Open AccessIL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer
Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1+, IL-1-high-signaling subtype of fibroblas...
-
Article
Open AccessIRF4 and BATF are critical for CD8+ T-cell function following infection with LCMV
CD8+ T-cell functions are critical for preventing chronic viral infections by eliminating infected cells. For healthy immune responses, beneficial destruction of infected cells must be balanced against immunopath...
-
Article
Open AccessReactive oxygen species delay control of lymphocytic choriomeningitis virus
Cluster of differentiation (CD)8+ T cells are like a double edged sword during chronic viral infections because they not only promote virus elimination but also induce virus-mediated immunopathology. Elevated lev...