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  1. Article

    Open Access

    IL1R1+ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer

    Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1+, IL-1-high-signaling subtype of fibroblas...

    E. Koncina, M. Nurmik, V. I. Pozdeev, C. Gilson, M. Tsenkova… in Nature Communications (2023)

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  2. No Access

    Article

    Peptide-based interference of the transmembrane domain of neuropilin-1 inhibits glioma growth in vivo

    Angiogenesis in glioblastoma is largely dependent on vascular endothelial growth factor (VEGF) signalling. Consistently, the VEGF coreceptor NRP1 promotes angiogenesis and tumour growth in gliomas. Here, we pr...

    C Nasarre, M Roth, L Jacob, L Roth, E Koncina, A Thien, G Labourdette, P Poulet… in Oncogene (2010)

  3. No Access

    Article

    The many faces of semaphorins: from development to pathology

    The semaphorin family is a large group of proteins controlling cell migration and axonal growth cone guidance. These proteins are bi-functional signals capable of growth promotion or growth inhibition. Initial...

    L. Roth, E. Koncina, S. Satkauskas, G. Crémel… in Cellular and Molecular Life Sciences (2008)