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Article

IL1R1⁺ cancer-associated fibroblasts drive tumor development and immunosuppression in colorectal cancer

Fibroblasts have a considerable functional and molecular heterogeneity and can play various roles in the tumor microenvironment. Here we identify a pro-tumorigenic IL1R1⁺, IL-1-high-signaling subtype of fibroblas...

E. Koncina, M. Nurmik, V. I. Pozdeev, C. Gilson, M. Tsenkova… in Nature Communications (2023)