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Open AccessFronto-thalamic networks and the left ventral thalamic nuclei play a key role in aphasia after thalamic stroke
Thalamic aphasia results from focal thalamic lesions that cause dysfunction of remote but functionally connected cortical areas due to language network perturbation. However, specific local and network-level n...
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Article
Open AccessStatistical analysis plan for the PRO B study: open-label, superiority randomised controlled trial of alarm-based patient-reported outcome monitoring in patients with metastatic breast cancer
With an increasing collection of patient-reported outcomes (PROs) to measure health-related quality of life (HRQoL) in oncological patients, there is still a lack of standardised strategies on how to interpret...
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Article
Open AccessCognitive training and brain stimulation in patients with cognitive impairment: a randomized controlled trial
Repeated sessions of training and non-invasive brain stimulation have the potential to enhance cognition in patients with cognitive impairment. We hypothesized that combining cognitive training with anodal tra...
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Article
Open AccessPatient perspective on task shifting from general practitioners to medical practice assistants – a quantitative survey in Germany
Various developments result in increasing workloads in general practices. New models of care and a restructuring of the division of tasks could provide relief. One approach is to extend the delegation of medic...
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Article
Open AccessPreconditioning of the motor network with repetitive navigated transcranial magnetic stimulation (rnTMS) to improve oncological and functional outcome in brain tumor surgery: a study protocol for a randomized, sham-controlled, triple-blind clinical trial
The extent of resection of glioma is one of the most important predictors of the survival duration of patients after surgery. The presence of eloquent areas within or near a tumor often limits resection, as re...
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Open AccessMicrostructural and functional plasticity following repeated brain stimulation during cognitive training in older adults
The combination of repeated behavioral training with transcranial direct current stimulation (tDCS) holds promise to exert beneficial effects on brain function beyond the trained task. However, little is known...
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Article
Open AccessExtent of routine diagnostic cardiac work-up at certified German stroke units participating in the prospective MonDAFIS study
About 25% of all ischaemic strokes are related to cardio-embolism, most often due to atrial fibrillation (AF). Little is known about the extent and standardization of routine cardiac diagnostic work-up at cert...
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Article
Open AccessRisk and course of COVID-19 in immunosuppressed patients with myasthenia gravis
Patients with myasthenia gravis (MG) are potentially prone for a severe COVID-19 course, but there are limited real-world data available on the risk associated with COVID-19 for patients with MG. Here, we inve...
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Open AccessCorrection to: Burden of disease in myasthenia gravis: taking the patient’s perspective
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Open AccessFear of prognosis? How anxiety, co**, and expected burden impact the decision to have cytogenetic assessment in uveal melanoma patients
Cytogenetic testing (CGT) in uveal melanoma patients reveals prognostic information about the individual risk of develo** distant metastasis with dismal prognosis. There is currently no medical intervention ...
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Open AccessCorrection: Effects of spermidine supplementation on cognition and biomarkers in older adults with subjective cognitive decline (SmartAge)—study protocol for a randomized controlled trial
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Article
Open AccessBurden of disease in myasthenia gravis: taking the patient’s perspective
Myasthenia gravis (MG) leads to exertion-dependent muscle weakness, but also psychological and social well-being are limited. We aim to describe the burden of disease in MG including sociodemographic, economic...
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Article
Open AccessIdentifying and handling unbalanced baseline characteristics in a non-randomized, controlled, multicenter social care nurse intervention study for patients in advanced stages of cancer
Given the psychosocial burdens patients in advanced stages of cancer face, innovative care concepts are needed. At the same time, such vulnerable patient groups are difficult to reach for participation in inte...
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Article
Open AccessAssociation of age with the timing of acute spine surgery–effects on neurological outcome after traumatic spinal cord injury
To investigate the association of age with delay in spine surgery and the effects on neurological outcome after traumatic spinal cord injury (SCI).
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Article
Open AccessPRO B: evaluating the effect of an alarm-based patient-reported outcome monitoring compared with usual care in metastatic breast cancer patients—study protocol for a randomised controlled trial
Despite the progress of research and treatment for breast cancer, still up to 30% of the patients afflicted will develop distant disease. Elongation of survival and maintaining the quality of life (QoL) become...
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Article
Open AccessSerum GFAP and NfL as disease severity and prognostic biomarkers in patients with aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder
Neuromyelitis optica spectrum disorder (NMOSD) is a frequently disabling neuroinflammatory syndrome with a relapsing course. Blood-based disease severity and prognostic biomarkers for NMOSD are a yet unmet cli...
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Open AccessCharacteristics and patient-reported outcomes associated with dropout in severely affected oncological patients: an exploratory study
Patient-reported outcome measures (PROMs) are commonly-used surrogates for clinical outcomes in cancer research. When researching severe diseases such as cancer, it is difficult to avoid the problem of incompl...
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Article
Open AccessBlinding in electric current stimulation in subacute neglect patients with current densities of 0.8 A/m2: a cross-over pilot study
Neglect after stroke is a disabling disorder and its rehabilitation is a major challenge. Transcranial direct current stimulation (tDCS) seems to be a promising adjuvant technique to improve standard care negl...
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Article
Open AccessCommunity care coordination for stroke survivors: results of a complex intervention study
Outpatient follow-up care for stroke survivors is often inadequate and mostly self-organized by the patients themselves. In the German health care system, there are no standard care programs for patients after...
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Article
Open AccessCognitive training and brain stimulation in prodromal Alzheimer’s disease (AD-Stim)—study protocol for a double-blind randomized controlled phase IIb (monocenter) trial
Given the growing older population worldwide, and the associated increase in age-related diseases, such as Alzheimer’s disease (AD), investigating non-invasive methods to ameliorate or even prevent cognitive d...
