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Open AccessErratum zu: Autoantikörperdiagnostik bei idiopathisch inflammatorischen Myopathien
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Open AccessAutoantikörperdiagnostik bei idiopathisch inflammatorischen Myopathien
Idiopathische inflammatorische Myopathien (IIM) sind eine Gruppe seltener und heterogener Systemerkrankungen, die sich nicht nur an der Muskulatur, sondern auch an der Haut, den Gelenken und der Lunge manifest...
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Article
Open AccessIdentification of gene expression biomarkers to predict clinical response to methotrexate in patients with rheumatoid arthritis
To identify biomarkers at the gene expression level to predict response to methotrexate (MTX) in patients with rheumatoid arthritis (RA).
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Article
Open AccessMeasuring PROMIS pain interference in German patients with chronic conditions: calibration, validation, and cross-cultural use of item parameters
To calibrate the item parameters of the German PROMIS® Pain interference (PROMIS PI) items using an item-response theory (IRT) model and investigate psychometric properties of the item bank.
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Article
Open AccessEconomic Effects of Fixed-Dose Versus Loose-Dose Combination Therapy for Type 2 Diabetes Patients
We examined the effects of fixe-dose combinations (FDCs) versus loose-dose combinations (LDCs) on costs from the payer and patient perspective and investigated potential channels contributing to differences in...
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Open AccessSkeletal muscle provides the immunological micro-milieu for specific plasma cells in anti-synthetase syndrome-associated myositis
Anti-synthetase syndrome (ASyS)-associated myositis is a major subgroup of the idiopathic inflammatory myopathies (IIM) and is characterized by disease chronicity with musculoskeletal, dermatological and pulmo...
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ISO/SAE 21434 - Der Standard für Sicherheit bei vernetzten Fahrzeugen
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ISO/SAE 21434 - The Standard for Security in Connected Cars
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Open AccessClinical manifestations and immunomodulatory treatment experiences in psychiatric patients with suspected autoimmune encephalitis: a case series of 91 patients from Germany
Autoimmune encephalitis (AE) can rarely manifest as a predominantly psychiatric syndrome without overt neurological symptoms. This study’s aim was to characterize psychiatric patients with AE; therefore, anony...
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Open AccessEvaluation of the EMPAR study population on the basis of metabolic phenotypes of selected pharmacogenes
The impact of genetic variability of pharmacogenes as a possible risk factor for adverse drug reactions is elucidated in the EMPAR (Einfluss metabolischer Profile auf die Arzneimitteltherapiesicherheit in der ...
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Article
Open AccessRegional variation in coronary angiography rates: the association with supply factors and the role of indication: a spatial analysis
Coronary angiographies (CAs) are among the most common diagnostic procedures carried out in German hospitals, and substantial regional differences in their frequency of use have been documented. Given the hete...
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Open AccessMacrophage activation syndrome in a patient with adult-onset Still’s disease following first COVID-19 vaccination with BNT162b2
Adult-onset Still’s disease (AOSD) is an autoinflammatory multi-systemic syndrome. Macrophage activation syndrome (MAS) is a potentially life-threatening complication of AOSD with a mortality rate of 10–20%. E...
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Open AccessPerformance of ENMC and EULAR/ACR classification systems applied to a single tertiary center cohort of dermatomyositis patients
There have been numerous classification systems to diagnose corresponding myositis subtypes and select appropriate therapeutic measures. However, the lack of a broad consensus on diagnostic criteria has led to...
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Open AccessImproving the continuity and coordination of ambulatory care through feedback and facilitated dialogue—a study protocol for a cluster-randomised trial to evaluate the ACD study (Accountable Care in Germany)
Patients in Germany are free to seek care from any office-based physician and can always ask for multiple opinions on a diagnosis or treatment. The high density of physicians and the freedom to choose among th...
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Open AccessThe impact of nurse staffing levels on nursing-sensitive patient outcomes: a multilevel regression approach
The goal of this study is to provide empirical evidence of the impact of nurse staffing levels on seven nursing-sensitive patient outcomes (NSPOs) at the hospital unit level. Combining a very large set of clai...
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Open AccessSystemic sclerosis-associated myositis features minimal inflammation and characteristic capillary pathology
Systemic sclerosis represents a chronic connective tissue disease featuring fibrosis, vasculopathy and autoimmunity, affecting skin, multiple internal organs, and skeletal muscles. The vasculopathy is consider...
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Open AccessTreatment-Related Healthcare Costs of Metastatic Castration-Resistant Prostate Cancer in Germany: A Claims Data Study
Treatments for patients with metastatic castration-resistant prostate cancer (mCRPC) have expanded rapidly. They include the chemotherapies docetaxel and cabazitaxel, hormonal drugs abiraterone and enzalutamid...
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Article
Open AccessThiamazol-induzierte Arthritis
Wir berichten über den Fall eines 42-jährigen Patienten mit akuter asymmetrischer Polyarthritis der großen und mittelgroßen Gelenke sowie Fieber und erhöhten serologischen Entzündungszeichen. Die Symptomatik b...
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Open AccessDo discontinuities in marginal reimbursement affect inpatient psychiatric care in Germany?
This paper examines the behaviour of mental health care providers in response to marginal payment incentives induced by a discontinuous per diem reimbursement schedule with varying tariff rates over the length...
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Open AccessIntensity dependent effect of cognitive training on motor cortical plasticity and cognitive performance in humans
Intervention-induced neuroplastic changes within the motor or cognitive system have been shown in the human brain. While cognitive and motor brain areas are densely interconnected, it is unclear whether this i...
