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Article
Open AccessThe HSV-1 ICP22 protein selectively impairs histone repositioning upon Pol II transcription downstream of genes
Herpes simplex virus 1 (HSV-1) infection and stress responses disrupt transcription termination by RNA Polymerase II (Pol II). In HSV-1 infection, but not upon salt or heat stress, this is accompanied by a dramat...
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Article
Open AccessChildhood sexual abuse is associated with higher total ghrelin serum levels in adulthood: results from a large, population-based study
Ghrelin is an orexigenic peptide hormone synthesized in times of stress and hunger and alterations of the ghrelin system following acute stressors could be repeatedly shown in humans. However, little data exis...
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Chapter and Conference Paper
Analyzing Parallel Applications for Unnecessary I/O Semantics that Inhibit File System Performance
Scalability and performance of I/O intensive parallel applications are major concerns in modern High Performance Computing (HPC) environments. Almost all applications use POSIX I/O explicitly or implicitly thr...
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Article
CDK11 regulates pre-mRNA splicing by phosphorylation of SF3B1
RNA splicing, the process of intron removal from pre-mRNA, is essential for the regulation of gene expression. It is controlled by the spliceosome, a megadalton RNA–protein complex that assembles de novo on ea...
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Article
Open AccessClinical manifestations and immunomodulatory treatment experiences in psychiatric patients with suspected autoimmune encephalitis: a case series of 91 patients from Germany
Autoimmune encephalitis (AE) can rarely manifest as a predominantly psychiatric syndrome without overt neurological symptoms. This study’s aim was to characterize psychiatric patients with AE; therefore, anony...
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Article
Open AccessAnti-NMDA receptor encephalitis and overlap** demyelinating disorder in a 20-year old female with borderline personality disorder: proposal of a diagnostic and therapeutic algorithm for autoimmune encephalitis in psychiatric patients “case report”
Anti-NMDA receptor encephalitis (NMDAR-E) is an autoimmune encephalitis (AE) mainly affecting young females. It typically presents with isolated psychiatric symptoms (e.g. depressed mood) at first and neurolog...
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Article
Open AccessPlexin-B2 facilitates glioblastoma infiltration by modulating cell biomechanics
Infiltrative growth is a major cause of high lethality of malignant brain tumors such as glioblastoma (GBM). We show here that GBM cells upregulate guidance receptor Plexin-B2 to gain invasiveness. Deletion of...
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Article
Microglia and macrophages promote corralling, wound compaction and recovery after spinal cord injury via Plexin-B2
Tissue repair after spinal cord injury requires the mobilization of immune and glial cells to form a protective barrier that seals the wound and facilitates debris clearing, inflammatory containment and matrix...
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Article
A randomized double-blind controlled trial to assess the benefits of amisulpride and olanzapine combination treatment versus each monotherapy in acutely ill schizophrenia patients (COMBINE): methods and design
This report presents the rationale and design of a multi-center clinical trial that examines the efficacy and safety of antipsychotic combination treatment in acutely ill schizophrenia patients compared to ant...
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Article
Open AccessCorrection to: Immunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer
Following publication of the original article [1], the authors have reported that Fig. 2 and Additional file 1: Figure S1, S2 partially show red scripts.
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Article
Open AccessImmunostimulatory RNA leads to functional reprogramming of myeloid-derived suppressor cells in pancreatic cancer
The tumor microenvironment (TME) combines features of regulatory cytokines and immune cell populations to evade the recognition by the immune system. Myeloid-derived suppressor cells (MDSC) comprise population...
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Article
Open AccessThe novel TRAIL-receptor agonist APG350 exerts superior therapeutic activity in pancreatic cancer cells
Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) has raised attention as a novel anticancer therapeutic as it induces apoptosis preferentially in tumor cells. However, first-generation TRAIL-rec...
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Article
Open AccessWatchdog – a workflow management system for the distributed analysis of large-scale experimental data
The development of high-throughput experimental technologies, such as next-generation sequencing, have led to new challenges for handling, analyzing and integrating the resulting large and diverse datasets. Bi...
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Article
Open AccessTranscriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1
The bromodomain protein Brd4 is an epigenetic reader and plays a critical role in the development and maintenance of leukemia. Brd4 binds to acetylated histone tails and activates transcription by recruiting t...
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Article
Peripheral monocytes are functionally altered and invade the CNS in ALS patients
Amyotrophic lateral sclerosis (ALS) is a devastating progressive neurodegenerative disease affecting primarily the upper and lower motor neurons. A common feature of all ALS cases is a well-characterized neuro...
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Article
Open AccessFrequency and relevance of psychoeducation in psychiatric diagnoses: Results of two surveys five years apart in German-speaking European countries
Psychoeducation has been shown to reduce relapse rates in several psychiatric disorders. Studies investigating for which psychiatric diagnoses psychoeducation is offered and assessing its perceived relevance c...
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Article
Towards I/O analysis of HPC systems and a generic architecture to collect access patterns
In high-performance computing applications, a high-level I/O call will trigger activities on a multitude of hardware components. These are massively parallel systems supported by huge storage systems and inter...
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Article
Open AccessMethylphenidate in mania project (MEMAP): study protocol of an international randomised double-blind placebo-controlled study on the initial treatment of acute mania with methylphenidate
Treatment of patients with acute mania remains a considerable medical challenge since onset of action of antimanic medication is delayed for several days. Psychostimulants could have an earlier onset of action...
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Chapter and Conference Paper
HPC File Systems in Wide Area Networks: Understanding the Performance of Lustre over WAN
Using the first commercially available 100 Gbps Ethernet technology with a link of varying length, we have evaluated the performance of the Lustre file system and its networking layer under different latency s...
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Chapter and Conference Paper
Trace-Based Analysis and Optimization for the Semtex CFD Application – Hidden Remote Memory Accesses and I/O Performance
In this paper we present the analysis and optimization of the Semtex CFD application on the basis of trace data obtained with VampirTrace and visualized by Vampir. In the course of the paper the evaluation of ...
