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Article
Open AccessFGF23 ameliorates ischemia-reperfusion induced acute kidney injury via modulation of endothelial progenitor cells: targeting SDF-1/CXCR4 signaling
The levels of fibroblast growth factor 23 (FGF23) rapidly increases after acute kidney injury (AKI). However, the role of FGF23 in AKI is still unclear. Here, we observe that pretreatment with FGF23 protein in...
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Article
Open AccessThe impact of baseline glomerular filtration rate on subsequent changes of glomerular filtration rate in patients with chronic kidney disease
Higher baseline glomerular filtration rate (GFR) may yield subsequent steeper GFR decline, especially in patients with diabetes mellitus (DM). However, this correlation in patients with chronic kidney disease ...
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Article
Open AccessAssociation between regional economic status and renal recovery of dialysis-requiring acute kidney injury among critically ill patients
The association between regional economic status and the probability of renal recovery among patients with dialysis-requiring AKI (AKI-D) is unknown. The nationwide prospective multicenter study enrolled criti...
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Article
Open AccessAre physicians on the same page about do-not-resuscitate? To examine individual physicians’ influence on do-not-resuscitate decision-making: a retrospective and observational study
Individual physicians and physician-associated factors may influence patients’/surrogates’ autonomous decision-making, thus influencing the practice of do-not-resuscitate (DNR) orders. The objective of this st...
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Article
Associations between preoperative continuation of renin–angiotensin system inhibitor and cardiac surgery-associated acute kidney injury: a propensity score-matching analysis
Cardiac surgery-associated acute kidney injury (CSA-AKI) is associated with high risk for complications and mortality. Whether renin–angiotensin system (RAS) inhibitor should be continued or withdrawn in patie...
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Article
Open AccessTo examine the associations between medical students’ conceptions of learning, strategies to learning, and learning outcome in a medical humanities course
By learning medical humanities, medical students are expected to shift from handling the diseases only to seeing a whole sick person. Therefore, understanding medical students’ learning process and outcomes of...
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Article
Open AccessPhysician workload associated with do-not-resuscitate decision-making in intensive care units: an observational study using Cox proportional hazards analysis
Physicians play a substantial role in facilitating communication regarding life-supporting treatment decision-making including do-not-resuscitate (DNR) in the intensive care units (ICU). Physician-related fact...
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Article
Open AccessUrinary biomarkers predict advanced acute kidney injury after cardiovascular surgery
Acute kidney injury (AKI) after cardiovascular surgery is a serious complication. Little is known about the ability of novel biomarkers in combination with clinical risk scores for prediction of advanced AKI.
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Article
Open AccessHemojuvelin Predicts Acute Kidney Injury and Poor Outcomes Following Cardiac Surgery
Acute kidney injury (AKI) is detrimental after cardiac surgery. In this multicenter study, the novel biomarker hemojuvelin (HJV) was evaluated for AKI prediction following cardiac surgery. Urinary HJV, neutrop...
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Article
Open AccessRenin-Angiotensin System Inhibitor is Associated with Lower Risk of Ensuing Chronic Kidney Disease after Functional Recovery from Acute Kidney Injury
Acute kidney injury (AKI) is an independent risk factor for ensuing chronic kidney disease (CKD). Animal studies have demonstrated that renin-angiotensin system (RAS) inhibitor can reduce ensuing CKD after fun...
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Article
Open AccessRestricted Use of Erythropoiesis-Stimulating Agent is Safe and Associated with Deferred Dialysis Initiation in Stage 5 Chronic Kidney Disease
The effect of erythropoiesis-stimulating agent (ESA) on dialysis initiation in advanced chronic kidney disease (CKD) patients is not clear. We retrospectively analyzed the outcome of dialysis initiation in a s...
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Article
Open AccessAcute kidney injury as a risk factor for diagnostic discrepancy among geriatric patients: a pilot study
Diagnostic discrepancy, defined as different admission and discharge diagnoses, could be a potential source of diagnostic error. We evaluated whether acute kidney injury (AKI) in the elderly affected their ris...
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Article
Open AccessLosartan reduces ensuing chronic kidney disease and mortality after acute kidney injury
Acute kidney injury (AKI) is an important risk factor for incident chronic kidney disease (CKD). Clinical studies disclose that ensuing CKD progresses after functional recovery from AKI, but the underlying mec...
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Article
Open AccessFurther deliberating the relationship between do-not-resuscitate and the increased risk of death
Few studies have examined the outcome of do-not-resuscitate (DNR) patients in surgical intensive care units (SICUs). This study deliberated the association between a DNR decision and the increased risk of deat...
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Article
Open AccessLong-term remote organ consequences following acute kidney injury
Acute kidney injury (AKI) has been a global health epidemic problem with soaring incidence, increased long-term risks for multiple comorbidities and mortality, as well as elevated medical costs. Despite the im...
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Article
Open AccessEffect of Treatment on Body Fluid in Patients with Unilateral Aldosterone Producing Adenoma: Adrenalectomy versus Spironolactone
Aldosterone affects fluid retention in the body by affecting how much salt and water that the kidney retains or excretes. There is limited information about the effect of prolonged aldosterone excess and treat...
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Article
Open AccessPrevalence and clinical correlates of somatic mutation in aldosterone producing adenoma-Taiwanese population
Primary aldosteronism (PA) is a common form of secondary hypertension and has significant cardiovascular consequences. Mutated channelopathy due to the activation of calcium channels has been recently describe...
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Article
Open AccessThe over-optimistic portrayal of life-supporting treatments in newspapers and on the Internet: a cross-sectional study using extra-corporeal membrane oxygenation as an example
Extra-corporeal membrane oxygenation has been introduced to clinical practice for several decades. It is unclear how internet and newspapers portray the use of extra-corporeal membrane oxygenation. This study ...
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Article
Dialysis-requiring acute kidney injury increases risk of long-term malignancy: a population-based study
Acute kidney injury (AKI) is gaining worldwide attention recently, emerging as a major public health threat. However, the association between the development of AKI and subsequent malignancy has not been stud...
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Article
Open AccessSignificant social events and increasing use of life-sustaining treatment: trend analysis using extracorporeal membrane oxygenation as an example
Most studies have examined the outcomes of patients supported by extracorporeal membrane oxygenation as a life-sustaining treatment. It is unclear whether significant social events are associated with the use ...
