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Article
Open AccessDiacylglycerol lipase alpha promotes hepatocellular carcinoma progression and induces lenvatinib resistance by enhancing YAP activity
As an important hydrolytic enzyme that yields 2-AG and free fatty acids, diacylglycerol lipase alpha (DAGLA) is involved in exacerbating malignant phenotypes and cancer progression, but the role of the DAGLA/2...
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Article
Risk prediction of nephropathy by integrating clinical and genetic information among adult patients with type 2 diabetes
Diabetic nephropathy (DN) is a major healthcare challenge. We developed and internally and externally validated a risk prediction model of DN by integrating clinical factors and SNPs from genes of multiple CKD...
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Article
Open AccessComparative accuracy of biomarkers for the prediction of hospital-acquired acute kidney injury: a systematic review and meta-analysis
Several biomarkers have been proposed to predict the occurrence of acute kidney injury (AKI); however, their efficacy varies between different trials. The aim of this study was to compare the predictive perfor...
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Article
Open AccessCircMEMO1 modulates the promoter methylation and expression of TCF21 to regulate hepatocellular carcinoma progression and sorafenib treatment sensitivity
Cirrhosis is a recognized risk factor for develo** hepatocellular carcinoma (HCC). Few studies have reported the expression profile of circRNAs in HCC samples compared to paratumour dysplastic nodule (DN) sa...
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Article
Open AccessAssociation between regional economic status and renal recovery of dialysis-requiring acute kidney injury among critically ill patients
The association between regional economic status and the probability of renal recovery among patients with dialysis-requiring AKI (AKI-D) is unknown. The nationwide prospective multicenter study enrolled criti...
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Article
Open AccessGenetic risk score for risk prediction of diabetic nephropathy in Han Chinese type 2 diabetes patients
We evaluated whether genetic information could offer improvement on risk prediction of diabetic nephropathy (DN) while adding susceptibility variants into a risk prediction model with conventional risk factors...
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Article
Three-dimensional weighting reconstruction algorithm for circular cone-beam CT under large scan angles
Improving imaging quality of cone-beam CT under large cone angle scan has been an important area of CT imaging research. Considering the idea of conjugate rays and making up missing data, we propose a three-di...
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Article
Permanent renal loss following tumor necrosis factor α antagonists for arthritis
Tumor necrosis factor α (TNF-α) antagonists are now widely used in the treatment of aggressive rheumatoid arthritis and are generally well tolerated. Although rare, they could induce systemic lupus erythematos...
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Article
Dishonest Behaviors in Online Rating Systems: Cyber Competition, Attack Models, and Attack Generator
Recently, online rating systems are gaining popularity. Dealing with unfair ratings in such systems has been recognized as an important but challenging problem. Many unfair rating detection approaches have bee...
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Article
The association between pulse pressure and vascular access thrombosis in chronic hemodialysis patients
Vascular access thrombosis (VAT) is a major cause of morbidity in chronic hemodialysis (HD) patients and is characterized by chronic inflammation. Pulse pressure (PP) is positively associated with chronic infl...
