-
Article
Open AccessImplications of unconventional histological subtypes on magnetic resonance imaging and oncological outcomes in patients who have undergone radical prostatectomy
The prognostic significance of unconventional histology (UH) subtypes including intraductal carcinoma of the prostate (IDC-P), ductal adenocarcinoma, and cribriform pattern has been investigated for prostate c...
-
Article
Clinical significance of location of perineural cancer invasion detected on prostate needle core biopsy
The clinical impact of site-specific perineural invasion (PNI) in prostate cancer remains poorly understood. We compared radical prostatectomy findings and oncologic outcomes in 434 patients with single-site P...
-
Article
Granulocyte-colony stimulating factor producing cervical cancer with elevated levels of parathyroid hormone-related protein: a case report and literature review
Systemic effects associated with hormones and cytokines secreted by tumor cells can cause paraneoplastic syndrome. Leukemoid reactions and hypercalcemia are relatively common manifestations of paraneoplastic s...
-
Article
Open AccessTumor immune microenvironment and clinical outcomes in stage IV urothelial cancer: YODO study
Bladder cancer is the 10th most common cancer globally, with a growing incidence in Japan. Evaluation of molecular, genetic, and cellular biomarkers that predict treatment response and prognosis in patients wi...
-
Article
Open AccessTrametinib improves Treg selectivity of anti-CCR4 antibody by regulating CCR4 expression in CTLs in oral squamous cell carcinoma
Regulatory T-cells (Tregs) play a major role in suppressing anti-tumor immune responses. Mogamulizumab, an anti-CC chemokine receptor type 4 (CCR4) monoclonal antibody, depletes effector Tregs (eTregs). Howeve...
-
Article
Open AccessCase report: surgical management of symptomatic pretracheal thyroid gland in a patient with dual ectopic thyroid
Dual ectopic thyroid, a very rare condition, is defined as the simultaneous presence of ectopic thyroid tissue in two abnormal locations. Here, we report the surgical management of a patient with dual ectopic ...
-
Article
NKX3.1 Expression in Salivary Gland “Intraductal” Papillary Mucinous Neoplasm: A Low-Grade Subtype of Salivary Gland Mucinous Adenocarcinoma
Salivary gland intraductal papillary mucinous neoplasm (SG IPMN) is a recently proposed entity characterized by a papillary-cystic proliferation of mucin-producing cells. Because of overlap** histologic feat...
-
Article
Open AccessMalignant testicular unclassified sex cord stromal tumor: a case report
Most testicular tumors are germ cell tumors; sex cord stromal tumors are infrequent, accounting for only 3–5% of testicular tumors. Unclassified sex cord stromal tumors are extremely rare. Generally, 10% of se...
-
Article
Open AccessA rapid and durable response to larotrectinib in a patient with NTRK fusion-positive secretory carcinoma originating from the external auditory canal
For decades, no clear consensus existed on the standard treatment option for malignant tumors of the external auditory canal, an extremely rare disease. Here we report the case of a 55-year-old female patient ...
-
Article
Open AccessDetection of perineural invasion in prostate needle biopsies with deep neural networks
The presence of perineural invasion (PNI) by carcinoma in prostate biopsies has been shown to be associated with poor prognosis. The assessment and quantification of PNI are, however, labor intensive. To aid p...
-
Article
A patient with very early onset FH-deficient renal cell carcinoma diagnosed at age seven
Hereditary leiomyomatosis and renal cell cancer (HLRCC) is caused by heterozygous germline variants in the fumarate hydratase (FH) gene and is associated with increased susceptibility to cutaneous leiomyomas, ute...
-
Article
TGFB1 mRNA expression is associated with poor prognosis and specific features of inflammation in ccRCC
To determine whether TGFB1 affects the immune microenvironment of ccRCC, we investigated the association between TGFB1 expression and clinicopathological features. Tissue microarray was generated from 158 total o...
-
Article
Open AccessElevated expression of B7 homolog 4 is associated with disease progression in upper urinary tract urothelial carcinoma
B7 homolog 4 (B7-H4) is a negative regulator of immune responses, but its immunoregulatory role in the tumor microenvironment of upper urinary tract urothelial carcinoma (UTUC) remains unclear.
-
Chapter
Adequacy of Urine Specimens (Adequacy)
Adequacy is a source of disagreement and controversy in cytopathology, and urinary tract specimens are no exception. For the purposes of this chapter, the term “adequacy” for urinary tract specimens is used to...
-
Chapter
High-Grade Urothelial Carcinoma (HGUC)
High-grade urothelial carcinoma (HGUC) is diagnosed using major criteria which include high N/C ratio, irregular nuclear membranes, and coarse chromatin. TPS second edition recognizes these criteria to be stri...
-
Article
Open AccessArtificial intelligence for diagnosis and Gleason grading of prostate cancer: the PANDA challenge
Artificial intelligence (AI) has shown promise for diagnosing prostate cancer in biopsies. However, results have been limited to individual studies, lacking validation in multinational settings. Competitions h...
-
Article
Open AccessCorrection to: Prognostic value of programmed death-ligand 1 status in Japanese patients with renal cell carcinoma
-
Article
Open AccessPrognostic value of programmed death-ligand 1 status in Japanese patients with renal cell carcinoma
Programmed death-ligand 1 (PD-L1) positivity is associated with poor prognosis in renal cell carcinoma (RCC). Because the prognostic impact and effect of confounding factors are less known, we investigated the...
-
Article
Open AccessPrimary leiomyoma of the ureter: a case report
Only 14 cases of leiomyoma with ureteral origin have been reported previously. Such primary leiomyomas often present as hydronephrosis, making the diagnosis difficult. Radical nephroureterectomy is often perfo...
-
Article
Open AccessIncreased expression of adenosine 2A receptors in metastatic renal cell carcinoma is associated with poorer response to anti-vascular endothelial growth factor agents and anti-PD-1/Anti-CTLA4 antibodies and shorter survival
Adenosine and its adenosine 2A receptors (A2AR) mediate the immunosuppressive mechanism by which tumors escape immunosurveillance and impede anti-tumor immunity within the tumor microenvironment. However, we d...
