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High-Grade Urothelial Carcinoma (HGUC)

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The Paris System for Reporting Urinary Cytology

Abstract

High-grade urothelial carcinoma (HGUC) is diagnosed using major criteria which include high N/C ratio, irregular nuclear membranes, and coarse chromatin. TPS second edition recognizes these criteria to be stringent in order to normalize the cytomorphologic heterogeneity of HGUC on urine samples and has included notable variances which may be present in urine samples. These variances are most notably N/C ratios that have a wide range in tumor cells and hypochromasia in select cases, along with HGUC sub-types, all of which impact cytologic interpretation. Degeneration of tumor cells also affects diagnosis of HGUC. The recognition of the major criteria and the variances will help in diagnosis of HGUC on cytologic specimens.

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Author information

Authors and Affiliations

  1. Department of Pathology and Laboratory Medicine, Weill Cornell Medicine, NY, New York, USA

    Momin T. Siddiqui

  2. Department of Pathology & Laboratory Medicine, University of Kentucky College of Medicine, Lexington, KY, USA

    Derek B. Allison

  3. Department Of Human Pathology of the Adulthood and of the Develo** Age, “Gaetano Barresi” of the University of Messina (Italy), Messina, Italy

    Guido Fadda

  4. Consultant in Pathology of the Foundation “Agostino Gemelli”, Hospital of the Catholic University of Rome, Rome, Italy

    Guido Fadda

  5. Department of Pathology, Inha University Hospital, Incheon, South Korea

    Jee-Young Han

  6. Department of Pathology, Cleveland Clinic, Cleveland, OH, USA

    Patrick J. McIntire

  7. Quest Diagnostics, Marlborough, MA, USA

    Christopher L. Owens

  8. University of California, San Francisco, San Francisco, CA, USA

    Z. Laura Tabatabai

  9. Department of Pathology, Aichi Medical University Hospital, Nagakute, Aichi, Japan

    Toyonori Tsuzuki

  10. Department of Pathology/Cytopathology, Massachusetts General Hospital, Boston, MA, USA

    Mingjuan Lisa Zhang

Authors
  1. Momin T. Siddiqui
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  2. Derek B. Allison
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  3. Guido Fadda
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  4. Jee-Young Han
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  5. Patrick J. McIntire
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  6. Christopher L. Owens
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  7. Z. Laura Tabatabai
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  8. Toyonori Tsuzuki
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  9. Mingjuan Lisa Zhang
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Corresponding author

Correspondence to Momin T. Siddiqui .

Editor information

Editors and Affiliations

  1. Department of Pathology, Loyola University Medical Center, Maywood, IL, USA

    Eva M. Wojcik

  2. Department of Pathology and Laboratory Medicine, University of Wisconsin School of Medicine and Public Health, Wisconsin State Laboratory of Hygiene, Madison, WI, USA

    Daniel F.I. Kurtycz

  3. Department of Pathology/Cytopathology, The Johns Hopkins University, Baltimore, MD, USA

    Dorothy L. Rosenthal

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Siddiqui, M.T. et al. (2022). High-Grade Urothelial Carcinoma (HGUC). In: Wojcik, E.M., Kurtycz, D.F., Rosenthal, D.L. (eds) The Paris System for Reporting Urinary Cytology. Springer, Cham. https://doi.org/10.1007/978-3-030-88686-8_6

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  • DOI: https://doi.org/10.1007/978-3-030-88686-8_6

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  • Publisher Name: Springer, Cham

  • Print ISBN: 978-3-030-88685-1

  • Online ISBN: 978-3-030-88686-8

  • eBook Packages: MedicineMedicine (R0)

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