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Article
Open AccessLigand-based design of [18F]OXD-2314 for PET imaging in non-Alzheimer’s disease tauopathies
Positron emission tomography (PET) imaging of tau aggregation in Alzheimer’s disease (AD) is hel** to map and quantify the in vivo progression of AD pathology. To date, no high-affinity tau-PET radiopharmace...
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Article
Open AccessDetection of perineural invasion in prostate needle biopsies with deep neural networks
The presence of perineural invasion (PNI) by carcinoma in prostate biopsies has been shown to be associated with poor prognosis. The assessment and quantification of PNI are, however, labor intensive. To aid p...
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Article
Open AccessTime to entry point and distal locking of intramedullary nails: a methodological phantom study comparing biplanar and uniplanar surgical imaging
Intramedullary nailing is the method of choice for diaphyseal fractures of the femur and tibia and is also commonly used to treat trochanteric hip fractures. Perioperative imaging is essential for visualising ...
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Article
Open AccessArtificial intelligence for diagnosis and Gleason grading of prostate cancer: the PANDA challenge
Artificial intelligence (AI) has shown promise for diagnosing prostate cancer in biopsies. However, results have been limited to individual studies, lacking validation in multinational settings. Competitions h...
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Article
Open AccessInterobserver reproducibility of perineural invasion of prostatic adenocarcinoma in needle biopsies
Numerous studies have shown a correlation between perineural invasion (PNI) in prostate biopsies and outcome. The reporting of PNI varies widely in the literature. While the interobserver variability of prosta...
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Article
Open AccessIdentification of areas of grading difficulties in prostate cancer and comparison with artificial intelligence assisted grading
The International Society of Urological Pathology (ISUP) hosts a reference image database supervised by experts with the purpose of establishing an international standard in prostate cancer grading. Here, we a...
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Article
Open AccessThe importance of study design in the application of artificial intelligence methods in medicine
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Article
Adherence to a healthy Nordic food index and breast cancer risk: results from a Swedish cohort study
A healthy Nordic dietary pattern has shown beneficial effects in relation to several chronic diseases. However, no study has evaluated the association between a healthy Nordic food index (HNFI) and risk of bre...
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Article
Proenkephalin A gene products activate a new family of sensory neuron–specific GPCRs
Several peptide fragments are produced by proteolytic cleavage of the opioid peptide precursor proenkephalin A, and among these are a number of enkephalin fragments, in particular bovine adrenal medulla peptid...
