7 Result(s)
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Toshiharu Ninomiya
Biomedicine
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Article
Open AccessBrain atrophy in normal older adult links tooth loss and diet changes to future cognitive decline
Several studies have found associations between poor oral health, particularly tooth loss and cognitive decline. However, the specific brain regions affected by tooth loss and the probable causes remain unclea...
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Article
Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
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Epidemiological Evidence of the Relationship Between Diabetes and Dementia
Growing epidemiological evidence has suggested that subjects with diabetes mellitus are at an increased risk for the development of dementia. However, the results for the subtypes of dementia are inconsistent....
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Article
Open AccessIntegrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer’s disease
Alzheimer’s disease (AD) is a common neurological disease that causes dementia in humans. Although the reports of associated pathological genes have been increasing, the molecular mechanism leading to the accu...
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Article
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Stroke has multiple etiologies, but the underlying genes and pathways are largely unknown. We conducted a multiancestry genome-wide-association meta-analysis in 521,612 individuals (67,162 cases and 454,450 co...
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Article
A nonsynonymous SNP in PRKCH (protein kinase C η) increases the risk of cerebral infarction
Cerebral infarction is the most common type of stroke and often causes long-term disability. To investigate the genetic contribution to cerebral infarction, we conducted a case-control study using 52,608 gene-...
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Article
Secular trends in the incidence, mortality, and survival rate of gastric cancer in a general Japanese population: the Hisayama study
To examine secular trends in the incidence and mortality of gastric cancer in a Japanese community, Hisayama, we established three study-cohorts of Hisayama residents aged ≥40 years in 1961 (1637 subjects), 19...
