-
Article
Open AccessSkin carotenoid scores and metabolic syndrome in a general Japanese population: the Hisayama study
Higher vegetable intake is being promoted as an initiative to prevent lifestyle-related diseases. Carotenoids are yellow or red pigment components and are widely present in vegetables. Since ingested carotenoi...
-
Article
Open AccessAssociation between masticatory function, frailty, and functional disability: an observational study
Increase in functional disability in aging societies is an international medical and public health issue. Masticatory function may be a potential risk factor for functional disability, but the role of frailty ...
-
Article
Open AccessAssociation between retinopathy and risk of dementia in a general Japanese population: the Hisayama Study
We investigated the association of retinopathy with the risk of dementia in a general older Japanese population. A total of 1709 population-based residents aged 60 years or older without dementia were followed...
-
Article
Open AccessSerum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD)
In recent years, the association between neuroinflammatory markers and dementia, especially Alzheimer’s disease (AD), has attracted much attention. However, the evidence for the relationship between serum-hs-C...
-
Article
Open AccessBrain atrophy in normal older adult links tooth loss and diet changes to future cognitive decline
Several studies have found associations between poor oral health, particularly tooth loss and cognitive decline. However, the specific brain regions affected by tooth loss and the probable causes remain unclea...
-
Article
Open AccessCorrection: Inadequate care and excessive overprotection during childhood are associated with the presence of Diabetes Mellitus in adulthood in a general Japanese population: a cross-sectional analysis from the Hisayama Study
-
Article
Open AccessInadequate care and excessive overprotection during childhood are associated with the presence of diabetes mellitus in adulthood in a general Japanese population: a cross-sectional analysis from the Hisayama Study
To investigate associations between parenting styles during childhood and diabetes in adulthood in a Japanese community.
-
Article
Secular trends in the prevalence, incidence, and progression of diabetic retinopathy: the Hisayama Study
To examine the secular trends in the prevalence, incidence, and progression rates of diabetic retinopathy (DR) in a Japanese community.
-
Article
Open AccessGenome-wide association study reveals BET1L associated with survival time in the 137,693 Japanese individuals
Human lifespan is reported to be heritable. Although previous genome-wide association studies (GWASs) have identified several loci, a limited number of studies have assessed the genetic associations with the r...
-
Article
The effect of the Kasuya CKD network on prevention of the progression of chronic kidney disease: successful collaboration of a public health service, primary care physicians and nephrologists—community based cohort study
In 2012, we established a CKD network in collaboration with the public health service, primary care physicians, and nephrologists in the Kasuya area. The aim of this study was to clarify if our CKD network was...
-
Article
Open AccessPublisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries
-
Article
Open AccessStroke genetics informs drug discovery and risk prediction across ancestries
Previous genome-wide association studies (GWASs) of stroke — the second leading cause of death worldwide — were conducted predominantly in populations of European ancestry1,2. Here, in cross-ancestry GWAS meta-an...
-
Article
Open AccessAssociation of the prefrailty with global brain atrophy and white matter lesions among cognitively unimpaired older adults: the Nakajima study
Physical frailty has been associated with adverse outcomes such as dementia. However, the underlying structural brain abnormalities of physical frailty are unclear. We investigated the relationship between phy...
-
Article
Open AccessAssociation of serum s-adenosylmethionine, s-adenosylhomocysteine, and their ratio with the risk of dementia and death in a community
We examined the association of serum s-adenosylmethionine (SAM), s-adenosylhomocysteine (SAH) (methionine metabolites), and their ratio on the risk of dementia and death in a community-dwelling population of o...
-
Article
Open AccessLong-term association of vegetable and fruit intake with risk of dementia in Japanese older adults: the Hisayama study
Several prospective Western studies have reported an inverse association of vegetable and fruit intake with dementia risk. However, there is limited epidemiologic evidence in Asians. This study investigated th...
-
Article
Open AccessAuthor Correction: Comparative profiling of cortical gene expression in Alzheimer’s disease patients and mouse models demonstrates a link between amyloidosis and neuroinflammation
-
Article
Development of a risk prediction model for incident hypertension in Japanese individuals: the Hisayama Study
The identification of individuals at high risk of develo** hypertension can be of great value to improve the efficiency of primary prevention strategies for hypertension. The objective of this study was to d...
-
Article
Comparison of the contributions of impaired beta cell function and insulin resistance to the development of type 2 diabetes in a Japanese community: the Hisayama Study
Our aim was to compare the contributions of impaired beta cell function (IBF) and insulin resistance with the development of type 2 diabetes in a Japanese community.
-
Article
Open AccessBlood n-3 fatty acid levels and total and cause-specific mortality from 17 prospective studies
The health effects of omega-3 fatty acids have been controversial. Here we report the results of a de novo pooled analysis conducted with data from 17 prospective cohort studies examining the associations betw...
-
Article
Open AccessUrinary N-terminal pro–B-type natriuretic peptide as a biomarker for cardiovascular events in a general Japanese population: the Hisayama Study
Epidemiological evidence has shown that serum N-terminal pro-brain natriuretic peptide (NT-proBNP) concentrations, a diagnostic biomarker for heart failure, are positively associated with cardiovascular risk. ...
