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  1. Article

    Open Access

    Integrated analysis of human genetic association study and mouse transcriptome suggests LBH and SHF genes as novel susceptible genes for amyloid-β accumulation in Alzheimer’s disease

    Alzheimer’s disease (AD) is a common neurological disease that causes dementia in humans. Although the reports of associated pathological genes have been increasing, the molecular mechanism leading to the accu...

    Yumi Yamaguchi-Kabata, Takashi Morihara, Tomoyuki Ohara… in Human Genetics (2018)

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  2. Article

    Open Access

    Laughter and humor as complementary and alternative medicines for dementia patients

    The number of dementia patients has increased worldwide, with an estimated 13.7 million dementia patients in the Asia Pacific region alone. This number is expected to increase to 64.6 million by the year 2050.

    Masatoshi Takeda, Ryota Hashimoto… in BMC Complementary and Alternative Medicine (2010)

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  3. No Access

    Chapter

    AD-FTLD Spectrum: New Understanding of the Neurodegenerative Process from the Study of Risk Genes

    Typical cases of primary neurodegenerative diseases causing dementia, such as Alzheimer’s disease (AD), diffuse Lewy body disease, frontotemporal lobar degeneration (FTLD), and corticobasal degeneration, show ...

    Masatoshi Takeda, Takashi Kudo, Toshihisa Tanaka… in Neuropsychiatric Disorders (2010)

  4. No Access

    Article

    Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease

    Defects in dendritic spines are common to several forms of cognitive deficits, including mental retardation and Alzheimer disease. Because mutation of p21-activated kinase (PAK) can lead to mental retardation ...

    Lixia Zhao, Qiu-Lan Ma, Frédéric Calon, Marni E Harris-White… in Nature Neuroscience (2006)

  5. Article

    Ibuprofen Suppresses Interleukin-1β Induction of Pro-Amyloidogenic α1-Antichymotrypsin to Ameliorate β-Amyloid (Aβ) Pathology in Alzheimer's Models

    Epidemiological and basic research suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) should protect against the most common forms of Alzheimer's disease (AD). Ibuprofen reduces amyloid (Aβ) pathology in...

    Takashi Morihara, Bruce Teter, Fusheng Yang, Giselle P Lim… in Neuropsychopharmacology (2005)

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  6. No Access

    Article

    Presenilin-1 mutations downregulate the signalling pathway of the unfolded-protein response

    Missense mutations in the human presenilin-1 (PS1) gene, which is found on chromosome 14, cause early-onset familial Alzheimer’s disease (FAD). FAD-linked PS1 variants alter proteolytic processing of the amyloid ...

    Taiichi Katayama, Kazunori Imaizumi, Naoya Sato, Ko Miyoshi… in Nature Cell Biology (1999)