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  1. No Access

    Article

    An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma

    Frequent loss of heterozygosity (LOH) on human chromosome 7q31 has been reported in numerous malignancies. Suppressor of tumorigenicity 7 (ST7) has been identified as a candidate tumor suppressor gene in this reg...

    Suna Wang, Yuriko Mori, Fumiaki Sato, **g Yin, Yan Xu, Tong-Tong Zou… in Oncogene (2003)

  2. No Access

    Article

    Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon

    In order to discover global gene expression patterns characterizing subgroups of colon cancer, microarrays were hybridized to labeled RNAs obtained from seventeen colonic specimens (nine carcinomas and eight n...

    Tong-Tong Zou, Florin M Selaru, Yan Xu, Valentina Shustova, **g Yin… in Oncogene (2002)

  3. No Access

    Article

    Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia

    A significant portion of gastric cancers exhibit defective DNA mismatch repair, manifested as microsatellite instability (MSI). High-frequency MSI (MSI-H) is associated with hypermethylation of the human mut-L ho...

    A Steven Fleisher, Manel Esteller, Gen Tamura, Asma Rashid, O Colin Stine… in Oncogene (2001)

  4. No Access

    Article

    Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal carcinoma cells

    The insulin-like growth factor II receptor (IGFIIR) has been implicated as a tumor suppressor gene in human malignancy. Frequent mutation, loss of heterozygosity, and microsatellite instability (MSI) directly ...

    Rhonda F Souza, Suna Wang, Manjusha Thakar, Kara N Smolinski, **g Yin… in Oncogene (1999)

  5. No Access

    Article

    FHIT gene alterations in esophageal cancer and ulcerative colitis (UC)

    FHIT (fragile histidine triad gene), a candidate tumor suppressor gene, was recently identified and cloned at chromosome 3p14.2. Alterations of this gene have been reported in a number of primary human tumors,...

    Tong-Tong Zou, Junyi Lei, Ying-Qiang Shi, **g Yin, Suna Wang, Rhonda F Souza… in Oncogene (1997)

  6. No Access

    Article

    Apparent protection from instability of repeat sequences in cancer-related genes in replication error positive gastrointestinal cancers

    Genomic instability at simple repeated sequences has been observed in various types of human cancers and is considered an important mechanism in tumorigenesis. Alterations at microsatellite loci have been repo...

    Lisa A Simms, Tong-Tong Zou, Joanne Young, Ying-Qiang Shi, Junyi Lei… in Oncogene (1997)