-
Article
Open AccessA large-scale television advertising dataset for detailed impression analysis
Creating impressive video content such as movies and advertisements is a very important yet challenging task in business that requires both a sense of creativity and a lot of experience. Even professionals can...
-
Article
Open AccessA protocol for coordinating post-tsunami field reconnaissance efforts in the USA
In the aftermath of a catastrophic tsunami, much is to be learned about tsunami generation and propagation, landscape and ecological changes, and the response and recovery of those affected by the disaster. Kn...
-
Article
Malignant solitary fibrous tumor with superior vena cava syndrome
Mediastinal solitary fibrous tumors, particularly those that are malignant, are rare. We report a case of malignant solitary fibrous tumor with superior vena cava syndrome and highly aggressive behavior. Posto...
-
Article
Frequent epigenetic silencing of the FHIT gene in penile squamous cell carcinomas
Methylation of normally unmethylated CpG-rich islands in or near the promoter region has been associated with transcriptional inactivation of tumor-suppressor and tumor-related genes in human cancers. However,...
-
Article
Hypomethylation of hepatocyte nuclear factor-1beta (HNF-1beta) CpG island in clear cell carcinoma of the ovary
Expression of hepatocyte nuclear factor-1beta (HNF-1beta) is significantly up-regulated in ovarian clear cell carcinoma (CCC). The mechanism of up-regulation, however, remains unclear. It has been recognized that...
-
Article
Hypermethylation of Chfr and hMLH1 in gastric noninvasive and early invasive neoplasias
Human tumors are genetically unstable, and the instability exists at two distinct levels—the chromosomal level and the nucleotide level. Chfr and hMLH1 hypermethylation, which may lead to chromosomal instability ...
-
Article
Variations in the C3, C3a receptor, and C5 genes affect susceptibility to bronchial asthma
Bronchial asthma (BA) is a common chronic inflammatory disease characterized by hyperresponsive airways, excess mucus production, eosinophil activation, and the production of IgE. The complement system plays a...
-
Article
Linkage and association of childhood asthma with the chromosome 12 genes
Several studies have shown linkage of chromosome region 12q13–24 to bronchial asthma and related phenotypes in ethnically diverse populations. In the Japanese population, a genome-wide study failed to show str...
-
Article
Age-related methylation of tumor suppressor and tumor-related genes: an analysis of autopsy samples
Age-related methylation may have the potential to behave as a mutator process. To clarify the physiological consequence of age-related methylation of tumor suppressor and tumor-related genes, we studied promot...
-
Article
Analysis of genetic and epigenetic alterations of the PTEN gene in gastric cancer
The PTEN tumor suppressor gene on 10q23.3, responsible for the Cowden and Bannayan-Zonana syndromes, encodes a dual-specificity phosphatase able to dephosphorylate both tyrosine phosphate and serine/threonine ph...
-
Article
Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia
A significant portion of gastric cancers exhibit defective DNA mismatch repair, manifested as microsatellite instability (MSI). High-frequency MSI (MSI-H) is associated with hypermethylation of the human mut-L ho...
-
Article
Distinct methylation patterns of two APC gene promoters in normal and cancerous gastric epithelia
The adenomatous polyposis coli (APC) tumor suppressor gene is mutationally inactivated in both familial and sporadic forms of colorectal cancers. In addition, hypermethylation of CpG islands in the upstream porti...
-
Article
Aberrations of theAPC gene in primary breast carcinoma
Aberrations of theAPC gene, which plays an important role in the genesis of familial adenomatous polyposis and colorectal carcinoma, were investigated in 31 surgical specimens of primary breast carcinoma. These s...
