-
Article
An LOH and mutational investigation of the ST7 gene locus in human esophageal carcinoma
Frequent loss of heterozygosity (LOH) on human chromosome 7q31 has been reported in numerous malignancies. Suppressor of tumorigenicity 7 (ST7) has been identified as a candidate tumor suppressor gene in this reg...
-
Article
Application of cDNA microarrays to generate a molecular taxonomy capable of distinguishing between colon cancer and normal colon
In order to discover global gene expression patterns characterizing subgroups of colon cancer, microarrays were hybridized to labeled RNAs obtained from seventeen colonic specimens (nine carcinomas and eight n...
-
Article
Hypermethylation of the hMLH1 gene promoter is associated with microsatellite instability in early human gastric neoplasia
A significant portion of gastric cancers exhibit defective DNA mismatch repair, manifested as microsatellite instability (MSI). High-frequency MSI (MSI-H) is associated with hypermethylation of the human mut-L ho...
-
Article
Expression of the wild-type insulin-like growth factor II receptor gene suppresses growth and causes death in colorectal carcinoma cells
The insulin-like growth factor II receptor (IGFIIR) has been implicated as a tumor suppressor gene in human malignancy. Frequent mutation, loss of heterozygosity, and microsatellite instability (MSI) directly ...
-
Article
FHIT gene alterations in esophageal cancer and ulcerative colitis (UC)
FHIT (fragile histidine triad gene), a candidate tumor suppressor gene, was recently identified and cloned at chromosome 3p14.2. Alterations of this gene have been reported in a number of primary human tumors,...
-
Article
Apparent protection from instability of repeat sequences in cancer-related genes in replication error positive gastrointestinal cancers
Genomic instability at simple repeated sequences has been observed in various types of human cancers and is considered an important mechanism in tumorigenesis. Alterations at microsatellite loci have been repo...